Literature DB >> 25773738

Seizures in setting of dementia.

Kartik Sivaraaman1, Vimala S Vajjala.   

Abstract

OPINION STATEMENT: Dementia, especially Alzheimer's disease, is an important cause of seizures and epilepsy midst the elderly. With the increasing life span, the incidence of dementia and epilepsy is expected to increase exponentially. Care of patients with advanced dementia can be demanding and seizures add to this burden. Though recognition of seizures in these patients can be difficult, seizures in these patients tend to be highly responsive to pharmacological therapy. However, choosing the right antiepileptic drug can be a challenge and complicated by altered kinetics and polypharmacy. While ongoing seizures can worsen the cognitive status in these patients, antiepileptic drugs could also add to the cognitive burden. The newer generation drugs show promise in terms of their side effect profile without compromising on the efficacy.

Entities:  

Year:  2015        PMID: 25773738     DOI: 10.1007/s11940-015-0342-9

Source DB:  PubMed          Journal:  Curr Treat Options Neurol        ISSN: 1092-8480            Impact factor:   3.598


  66 in total

1.  Seizures in Alzheimer's disease: a retrospective study of a cohort of outpatients.

Authors:  Silvia Bernardi; Nicola Scaldaferri; Nicola Vanacore; Alessandro Trebbastoni; Ada Francia; Aurelio D'Amico; Massimiliano Prencipe
Journal:  Epileptic Disord       Date:  2010-02-22       Impact factor: 1.819

2.  Etiology and patterns of seizures in the elderly.

Authors:  M B Sundaram
Journal:  Neuroepidemiology       Date:  1989       Impact factor: 3.282

Review 3.  Epilepsy in elderly people.

Authors:  L J Stephen; M J Brodie
Journal:  Lancet       Date:  2000-04-22       Impact factor: 79.321

Review 4.  Enzyme induction with antiepileptic drugs: cause for concern?

Authors:  Martin J Brodie; Scott Mintzer; Alison M Pack; Barry E Gidal; Charles J Vecht; Dieter Schmidt
Journal:  Epilepsia       Date:  2012-09-27       Impact factor: 5.864

Review 5.  Seizures in the elderly: Nuances in presentation and treatment.

Authors:  Elizabeth Waterhouse; Alan Towne
Journal:  Cleve Clin J Med       Date:  2005-10       Impact factor: 2.321

6.  Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy.

Authors:  Rimante Minkeviciene; Sylvain Rheims; Marton B Dobszay; Misha Zilberter; Jarmo Hartikainen; Lívia Fülöp; Botond Penke; Yuri Zilberter; Tibor Harkany; Asla Pitkänen; Heikki Tanila
Journal:  J Neurosci       Date:  2009-03-18       Impact factor: 6.167

7.  Effects of antiepileptic drugs on lipids, homocysteine, and C-reactive protein.

Authors:  Scott Mintzer; Christopher T Skidmore; Caitlin J Abidin; Megan C Morales; Inna Chervoneva; David M Capuzzi; Michael R Sperling
Journal:  Ann Neurol       Date:  2009-04       Impact factor: 10.422

8.  A randomized, double-blind, placebo-controlled trial of donepezil to improve memory in epilepsy.

Authors:  Marla J Hamberger; Christina A Palmese; Nikolaos Scarmeas; David Weintraub; Hyunmi Choi; Lawrence J Hirsch
Journal:  Epilepsia       Date:  2007-05-01       Impact factor: 5.864

Review 9.  Specific binding of lacosamide to collapsin response mediator protein 2 (CRMP2) and direct impairment of its canonical function: implications for the therapeutic potential of lacosamide.

Authors:  Sarah M Wilson; Rajesh Khanna
Journal:  Mol Neurobiol       Date:  2014-06-20       Impact factor: 5.590

Review 10.  Epileptic seizures in AD patients.

Authors:  A J Larner
Journal:  Neuromolecular Med       Date:  2009-06-26       Impact factor: 3.843

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