Bennett Levitan1, Michael Markowitz1, Ateesha F Mohamed1, F Reed Johnson1, Larry Alphs1, Leslie Citrome1, John F P Bridges1. 1. Dr. Levitan is with Janssen Research and Development, L.L.C., Titusville, New Jersey (e-mail: blevitan@its.jnj.com ). Dr. Markowitz was with Janssen Scientific Affairs, L.L.C., Titusville, and Ms. Mohamed and Dr. Johnson were with RTI Health Solutions, Research Triangle Park, North Carolina, during a large portion of the time that the study was conducted. Dr. Markowitz is now with the Department of Biopharma Development Solutions, CNS Practice, UCB Biosciences, Inc., Raleigh, North Carolina. Ms. Mohamed is now with Global Health Economics and Outcomes Research, Specialty Medicine, Bayer Healthcare Pharmaceuticals, Inc., Whippany, New Jersey. Dr. Johnson is now with the Center for Clinical and Genetic Economics, Duke Clinical Research Institute, Durham, North Carolina. Dr. Alphs is with Janssen Scientific Affairs, L.L.C. Dr. Citrome is with the Department of Psychiatry and Behavioral Sciences, New York Medical College, Valhalla. Dr. Bridges is with the Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore.
Abstract
OBJECTIVE: The objective of this study was to quantify patients' preferences related to benefits and risks of antipsychotic treatments for schizophrenia and to assess the relative importance of treatment attributes and adherence. METHODS: Treatment-related preferences among U.S. residents with a self-reported physician diagnosis of schizophrenia were assessed via a discrete-choice experiment. Patients chose between competing hypothetical scenarios characterized by improvements in positive symptoms, negative symptoms, and social functioning; incidence of weight gain, extrapyramidal symptoms (EPS), hyperprolactinemia, and hyperglycemia; and medication formulation. Preferences were estimated by using a random-parameters logit model, and the impact of adherence was estimated with conditional logit models. RESULTS: The final sample consisted of 271 patients. Complete improvement in positive symptoms was the most preferred outcome (relative importance score of 10.0), followed by elimination of hyperglycemia (3.6, 95% confidence interval [CI]=2.6-4.6), improvement in negative symptoms (3.0, CI=1.6-4.3), reduced weight gain (2.6, CI=1.2-4.0), avoidance of hyperprolactinemia (1.7, CI=.9-2.6), improved social functioning (1.5, CI=.4-2.5), and avoidance of EPS (1.0, CI=.3-1.8). Patients judged a daily pill superior to monthly injections (p<.01) and monthly injections superior to injections every three months (p<.01) for adherent patients and monthly injections superior to a daily pill for nonadherent patients (p=.01). CONCLUSIONS: Persons who self-identified as having schizophrenia judged improvement in positive symptoms as the most important treatment benefit. Hyperglycemia was identified as the most important adverse event. Patients judged oral formulations to be better than monthly injections for adherent patients and monthly injections to be a better choice for nonadherent patients.
OBJECTIVE: The objective of this study was to quantify patients' preferences related to benefits and risks of antipsychotic treatments for schizophrenia and to assess the relative importance of treatment attributes and adherence. METHODS: Treatment-related preferences among U.S. residents with a self-reported physician diagnosis of schizophrenia were assessed via a discrete-choice experiment. Patients chose between competing hypothetical scenarios characterized by improvements in positive symptoms, negative symptoms, and social functioning; incidence of weight gain, extrapyramidal symptoms (EPS), hyperprolactinemia, and hyperglycemia; and medication formulation. Preferences were estimated by using a random-parameters logit model, and the impact of adherence was estimated with conditional logit models. RESULTS: The final sample consisted of 271 patients. Complete improvement in positive symptoms was the most preferred outcome (relative importance score of 10.0), followed by elimination of hyperglycemia (3.6, 95% confidence interval [CI]=2.6-4.6), improvement in negative symptoms (3.0, CI=1.6-4.3), reduced weight gain (2.6, CI=1.2-4.0), avoidance of hyperprolactinemia (1.7, CI=.9-2.6), improved social functioning (1.5, CI=.4-2.5), and avoidance of EPS (1.0, CI=.3-1.8). Patients judged a daily pill superior to monthly injections (p<.01) and monthly injections superior to injections every three months (p<.01) for adherent patients and monthly injections superior to a daily pill for nonadherent patients (p=.01). CONCLUSIONS:Persons who self-identified as having schizophrenia judged improvement in positive symptoms as the most important treatment benefit. Hyperglycemia was identified as the most important adverse event. Patients judged oral formulations to be better than monthly injections for adherent patients and monthly injections to be a better choice for nonadherent patients.
Authors: Nichole Goodsmith; Amy N Cohen; Anthony W P Flynn; Alison B Hamilton; Gerhard Hellemann; Nancy Nowlin-Finch; Alexander S Young Journal: Psychiatr Serv Date: 2021-01-12 Impact factor: 3.084
Authors: Leslie Citrome; Joseph P McEvoy; Mark S Todtenkopf; David McDonnell; Peter J Weiden Journal: Neuropsychiatr Dis Treat Date: 2019-09-05 Impact factor: 2.570