| Literature DB >> 25772077 |
Rong Li1, Chen Huang, Jian Chen, Yang Guo, Sheng Tan.
Abstract
Uric acid (UA), a product of purine metabolism, is a kind of powerful endogenous antioxidant which may increase in many oxidative stress situations such as stroke. Some studies have found that UA is a predictor for stroke by mechanisms involved in development. There are some controversies about whether it is an independent effect of UA or an epiphenomenon. UA has been widely concerned for its neuroprotective effect as an antioxidant. In some experimental models of acute ischemic stroke, UA levels are associated with better functional recovery because of its synergistic effect with alteplase. In this review, a comprehensive literature search was conducted through Pubmed (1980-October 2014) to review the association of UA with the outcome of stroke. Finally, we outline the available clinical trial data supporting UA as a type of neuroprotective agents for the ischemic stroke.Entities:
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Year: 2015 PMID： 25772077 DOI： 10.1007/s10072-015-2151-z
Source DB: PubMed Journal: Neurol Sci ISSN： 1590-1874 Impact factor: 3.307