Literature DB >> 25772041

From Mice to Men: TRPC3 in Cerebellar Ataxia.

Esther B E Becker1.   

Abstract

The dominantly inherited cerebellar ataxias are a clinically and genetically heterogeneous group of neurodegenerative disorders. Studies using mouse models as well as recent genetic and transcriptomic human findings point to an important role for TRPC3 signaling in cerebellar ataxia.

Entities:  

Keywords:  Ataxia; Calcium signaling; Purkinje cell; TRPC3; mGluR1

Mesh：

Substances：

Year:  2017        PMID： 25772041      PMCID： PMC6034647          DOI： 10.1007/s12311-015-0663-y

Source DB:  PubMed          Journal:  Cerebellum        ISSN： 1473-4222            Impact factor:   3.847


  10 in total

Review 1.  Molecular and cellular control of dendrite maturation during brain development.

Authors:  F Metzger
Journal:  Curr Mol Pharmacol       Date:  2010-01       Impact factor: 3.339

2.  Do mutations in the murine ataxia gene TRPC3 cause cerebellar ataxia in humans?

Authors:  Brent L Fogel; Sonya M Hanson; Esther B E Becker
Journal:  Mov Disord       Date:  2014-12-05       Impact factor: 10.338

3.  TRPC3 channels are required for synaptic transmission and motor coordination.

Authors:  Jana Hartmann; Elena Dragicevic; Helmuth Adelsberger; Horst A Henning; Martin Sumser; Joel Abramowitz; Robert Blum; Alexander Dietrich; Marc Freichel; Veit Flockerzi; Lutz Birnbaumer; Arthur Konnerth
Journal:  Neuron       Date:  2008-08-14       Impact factor: 17.173

4.  TRPC3 channel underlies cerebellar long-term depression.

Authors:  Sang Jeong Kim
Journal:  Cerebellum       Date:  2013-06       Impact factor: 3.847

5.  Cerebellar modules operate at different frequencies.

Authors:  Haibo Zhou; Zhanmin Lin; Kai Voges; Chiheng Ju; Zhenyu Gao; Laurens W J Bosman; Tom J H Ruigrok; Freek E Hoebeek; Chris I De Zeeuw; Martijn Schonewille
Journal:  Elife       Date:  2014-05-07       Impact factor: 8.140

Review 6.  The Moonwalker mouse: new insights into TRPC3 function, cerebellar development, and ataxia.

Authors:  Esther B E Becker
Journal:  Cerebellum       Date:  2014-10       Impact factor: 3.847

7.  A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice.

Authors:  Esther B E Becker; Peter L Oliver; Maike D Glitsch; Gareth T Banks; Francesca Achilli; Andrea Hardy; Patrick M Nolan; Elizabeth M C Fisher; Kay E Davies
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-07       Impact factor: 11.205

8.  Insights from cerebellar transcriptomic analysis into the pathogenesis of ataxia.

Authors:  Conceição Bettencourt; Mina Ryten; Paola Forabosco; Stephanie Schorge; Joshua Hersheson; John Hardy; Henry Houlden
Journal:  JAMA Neurol       Date:  2014-07-01       Impact factor: 18.302

9.  Candidate screening of the TRPC3 gene in cerebellar ataxia.

Authors:  Esther B E Becker; Brent L Fogel; Sanjeev Rajakulendran; Anna Dulneva; Michael G Hanna; Susan L Perlman; Daniel H Geschwind; Kay E Davies
Journal:  Cerebellum       Date:  2011-06       Impact factor: 3.847

10.  Next generation sequencing for molecular diagnosis of neurological disorders using ataxias as a model.

Authors:  Andrea H Németh; Alexandra C Kwasniewska; Stefano Lise; Ricardo Parolin Schnekenberg; Esther B E Becker; Katarzyna D Bera; Morag E Shanks; Lorna Gregory; David Buck; M Zameel Cader; Kevin Talbot; Rajith de Silva; Nicholas Fletcher; Rob Hastings; Sandeep Jayawant; Patrick J Morrison; Paul Worth; Malcolm Taylor; John Tolmie; Mary O'Regan; Ruth Valentine; Emily Packham; Julie Evans; Anneke Seller; Jiannis Ragoussis
Journal:  Brain       Date:  2013-09-11       Impact factor: 13.501
  10 in total
  5 in total

1.  TRPC3 Channel Activity and Viability of Purkinje Neurons can be Regulated by a Local Signalosome.

Authors:  Naveed Aslam; Farah Alvi
Journal:  Front Mol Biosci       Date:  2022-02-21

2.  Neurodegeneration in SCA14 is associated with increased PKCγ kinase activity, mislocalization and aggregation.

Authors:  Maggie M K Wong; Stephanie D Hoekstra; Jane Vowles; Lauren M Watson; Geraint Fuller; Andrea H Németh; Sally A Cowley; Olaf Ansorge; Kevin Talbot; Esther B E Becker
Journal:  Acta Neuropathol Commun       Date:  2018-09-24       Impact factor: 7.801

Review 3.  Disrupted Calcium Signaling in Animal Models of Human Spinocerebellar Ataxia (SCA).

Authors:  Francesca Prestori; Francesco Moccia; Egidio D'Angelo
Journal:  Int J Mol Sci       Date:  2019-12-27       Impact factor: 5.923

4.  Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule-Purkinje Neuron Synaptic Strength.

Authors:  Aleksandar Arsović; Melanie Vanessa Halbach; Júlia Canet-Pons; Dilhan Esen-Sehir; Claudia Döring; Florian Freudenberg; Nicoletta Czechowska; Kay Seidel; Stephan L Baader; Suzana Gispert; Nesli-Ece Sen; Georg Auburger
Journal:  Int J Mol Sci       Date:  2020-09-12       Impact factor: 5.923

5.  Region-specific preservation of Purkinje cell morphology and motor behavior in the ATXN1[82Q] mouse model of spinocerebellar ataxia 1.

Authors:  Joshua J White; Laurens W J Bosman; Francois G C Blot; Catarina Osório; Bram W Kuppens; Wilhelmina H J J Krijnen; Charlotte Andriessen; Chris I De Zeeuw; Dick Jaarsma; Martijn Schonewille
Journal:  Brain Pathol       Date:  2021-03-16       Impact factor: 6.508
  5 in total

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