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Literature DB >> 25771120

Kaennacowanols A-C, three new xanthones and their cytotoxicity from the roots of Garcinia cowa.

Sutin Kaennakam¹, Pongpun Siripong², Santi Tip-Pyang³.

Abstract

Three new xanthones, named kaennacowanols A-C (1-3), along with nineteen known xanthones were isolated from the roots of Garcinia cowa Roxb. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against KB and HeLa cell lines. Compounds 17 and 22 showed good cytotoxicity against KB cell with IC50 values of 7.97 and 9.10μM, respectively. On the other hand, compound 15 showed good cytotoxicity against HeLa cell with IC50 value of 9.34μM.

Entities: Chemical Disease Species

Keywords: Clusiaceae; Cytotoxicity; Garcinia cowa; Kaennacowanols A–C; Xanthone

Mesh：

Substances：

Year: 2015 PMID： 25771120 DOI： 10.1016/j.fitote.2015.03.008

Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882

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Cited

3 in total

Kaennacowanols A-C, three new xanthones and their cytotoxicity from the roots of Garcinia cowa.

1. Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana.

2. Cytotoxic and Anti-Inflammatory Activities of Dihydroisocoumarin and Xanthone Derivatives from Garcinia picrorhiza.

Review 3. Chemical and Biological Research on Herbal Medicines Rich in Xanthones.