Youssef H Zeidan1, Leonid Pekelis2, Yi An3, Floyd Christopher Holsinger4, Christina S Kong5, Daniel T Chang6, Quynh-Thu Le6. 1. Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, United States. Electronic address: zeidan@miami.edu. 2. Department of Statistics, Stanford University, Stanford, CA, United States. 3. Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, United States. 4. Division of Head & Neck Surgery, Department of Otolaryngology, Stanford University School of Medicine, Stanford, CA, United States. 5. Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States. 6. Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, United States.
Abstract
OBJECTIVES: The goal of the current study is to investigate the role of adjuvant radiation therapy (adjuvant RT) in minor salivary gland tumors (mSGT) using an established national database. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients treated with or without adjuvant RT for mSGT from 1988 to 2008. Regression analyses were performed to identify factors associated with improved overall survival (OS). RESULTS: Most tumors were located within the oral cavity (75%) followed by nasal cavity/paranasal sinuses (15%). Multivariate Cox analysis showed that adjuvant RT was associated with better OS compared to surgery alone. Using logistic regression analysis, we provide a novel web based tool for predicting survival impact of adjuvant RT in patients with mSGT. CONCLUSIONS: Adjuvant RT is associated with improved survival in patients with mSGT and adverse clinicopathologic factors such as advanced T/N category, adenoid cystic histology, high grade, and nasopharynx location.
OBJECTIVES: The goal of the current study is to investigate the role of adjuvant radiation therapy (adjuvant RT) in minor salivary gland tumors (mSGT) using an established national database. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify patients treated with or without adjuvant RT for mSGT from 1988 to 2008. Regression analyses were performed to identify factors associated with improved overall survival (OS). RESULTS: Most tumors were located within the oral cavity (75%) followed by nasal cavity/paranasal sinuses (15%). Multivariate Cox analysis showed that adjuvant RT was associated with better OS compared to surgery alone. Using logistic regression analysis, we provide a novel web based tool for predicting survival impact of adjuvant RT in patients with mSGT. CONCLUSIONS: Adjuvant RT is associated with improved survival in patients with mSGT and adverse clinicopathologic factors such as advanced T/N category, adenoid cystic histology, high grade, and nasopharynx location.
Authors: Katri Aro; Allen S Ho; Michael Luu; Sungjin Kim; Mourad Tighiouart; Jon Mallen-St Clair; Emi J Yoshida; Stephen L Shiao; Ilmo Leivo; Zachary S Zumsteg Journal: Cancer Date: 2018-05-09 Impact factor: 6.860
Authors: J Rhet Tucker; Li Xu; Erich M Sturgis; Abdallah S R Mohamed; Theresa M Hofstede; Mark S Chambers; Stephen Y Lai; Clifton David Fuller; Beth Beadle; G Brandon Gunn; Katherine A Hutcheson Journal: Oral Oncol Date: 2016-03-31 Impact factor: 5.337