Laurence G Trahair1, Michael Horowitz1, Karen L Jones2. 1. Discipline of Medicine, The University of Adelaide, Adelaide, South Australia; National Health and Medical Research Council, Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia. 2. Discipline of Medicine, The University of Adelaide, Adelaide, South Australia; National Health and Medical Research Council, Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia. Electronic address: karen.jones@adelaide.edu.au.
Abstract
BACKGROUND: Postprandial hypotension (PPH) occurs frequently in older individuals with disease and/or living in residential care, but its prevalence in "healthy" older individuals has not been evaluated in large cohorts. PPH is associated with substantial morbidity and increased mortality; current management is suboptimal. Recent studies suggest that the magnitude of the postprandial fall in blood pressure (BP) is related to the rate of gastric emptying (GE), so that relatively more rapid GE may potentially be a risk factor for PPH. We aimed to determine the prevalence of, and evaluate the association of GE with PPH. METHODS: A total of 88 healthy "older", community-dwelling residents (47 women, 41 men; age 71.0 ± 0.5 years) attended a clinical research laboratory on a single occasion. Individuals consumed a 300 mL drink containing 75 g glucose and 150 mg C(13)-acetate. Exhaled breath was obtained for analysis of (13)CO2 and calculation of the 50% GE time (T50). BP and heart rate were assessed with an automated device. RESULTS: Eleven (12.8%) of 86 subjects had PPH (2 had diabetes and were excluded). GE was faster in subjects with PPH than the remainder of the group (T50 118.0 ± 9.4 vs 142.3 ± 4.6 minutes, P < .05). CONCLUSIONS: We conclude the prevalence of PPH in a cohort of otherwise healthy "older" individuals is 12.8% and PPH is associated with relatively more rapid GE. Therapies that slow GE may be useful in the management of PPH.
BACKGROUND: Postprandial hypotension (PPH) occurs frequently in older individuals with disease and/or living in residential care, but its prevalence in "healthy" older individuals has not been evaluated in large cohorts. PPH is associated with substantial morbidity and increased mortality; current management is suboptimal. Recent studies suggest that the magnitude of the postprandial fall in blood pressure (BP) is related to the rate of gastric emptying (GE), so that relatively more rapid GE may potentially be a risk factor for PPH. We aimed to determine the prevalence of, and evaluate the association of GE with PPH. METHODS: A total of 88 healthy "older", community-dwelling residents (47 women, 41 men; age 71.0 ± 0.5 years) attended a clinical research laboratory on a single occasion. Individuals consumed a 300 mL drink containing 75 g glucose and 150 mg C(13)-acetate. Exhaled breath was obtained for analysis of (13)CO2 and calculation of the 50% GE time (T50). BP and heart rate were assessed with an automated device. RESULTS: Eleven (12.8%) of 86 subjects had PPH (2 had diabetes and were excluded). GE was faster in subjects with PPH than the remainder of the group (T50 118.0 ± 9.4 vs 142.3 ± 4.6 minutes, P < .05). CONCLUSIONS: We conclude the prevalence of PPH in a cohort of otherwise healthy "older" individuals is 12.8% and PPH is associated with relatively more rapid GE. Therapies that slow GE may be useful in the management of PPH.
Authors: D Schoevaerdts; M Iacovelli; E Toussaint; F-X Sibille; M de Saint-Hubert; G Cremer Journal: J Nutr Health Aging Date: 2019 Impact factor: 4.075
Authors: Laurence G Trahair; Sharmalar Rajendran; Renuka Visvanathan; Matthew Chapman; Daniel Stadler; Michael Horowitz; Karen L Jones Journal: Physiol Rep Date: 2017-07
Authors: Laurence G Trahair; Tongzhi Wu; Christine Feinle-Bisset; Chinmay S Marathe; Christopher K Rayner; Michael Horowitz; Karen L Jones Journal: Physiol Rep Date: 2018-02
Authors: Emidio Scarpellini; Joris Arts; George Karamanolis; Anna Laurenius; Walter Siquini; Hidekazu Suzuki; Andrew Ukleja; Andre Van Beek; Tim Vanuytsel; Serhat Bor; Eugene Ceppa; Carlo Di Lorenzo; Marloes Emous; Heinz Hammer; Per Hellström; Martine Laville; Lars Lundell; Ad Masclee; Patrick Ritz; Jan Tack Journal: Nat Rev Endocrinol Date: 2020-05-26 Impact factor: 43.330
Authors: Hung Pham; Iselin S Holen; Liza K Phillips; Seva Hatzinikolas; Lian Q Huynh; Tongzhi Wu; Trygve Hausken; Christopher K Rayner; Michael Horowitz; Karen L Jones Journal: Nutrients Date: 2019-11-05 Impact factor: 5.717