| Literature DB >> 25769714 |
Paul J Speicher1, Claire H Meriwether1, Douglas S Tyler2.
Abstract
In-transit melanoma is an uncommon pattern of recurrence, but presents unique management challenges and opportunities for treatment. The clinical presentation usually involves from 1 to more than 100 small subcutaneous or cutaneous nodules, ranging from submillimeter to multiple centimeters in diameter. Regional chemotherapy techniques are a mainstay of treatment of patients without systemic disease spread. Future applications of regional therapy are likely to involve combination therapy with cytotoxic agents and novel immune modulators. Regional therapy provides distinct opportunities for the treatment of unresectable disease, and offers a unique platform for investigation of novel therapeutics in early-stage clinical trials. Published by Elsevier Inc.Entities:
Keywords: In-transit melanoma; Isolated limb infusion; Isolated limb perfusion; Regional therapy
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Year: 2015 PMID: 25769714 PMCID: PMC5161093 DOI: 10.1016/j.soc.2014.12.008
Source DB: PubMed Journal: Surg Oncol Clin N Am ISSN: 1055-3207 Impact factor: 3.495