Manja Koch1, Jan Borggrefe2, Sabrina Schlesinger1, Janett Barbaresko3, Godo Groth4, Gunnar Jacobs5, Wolfgang Lieb6, Matthias Laudes7, Manfred J Müller8, Anja Bosy-Westphal9, Martin Heller4, Ute Nöthlings3. 1. Institute of Epidemiology, Christian-Albrechts University Kiel, Kiel, Germany Institute of Experimental Medicine, Christian-Albrechts University Kiel, Kiel, Germany. 2. Department of Radiology, University of Cologne, Cologne, Germany. 3. Institute of Experimental Medicine, Christian-Albrechts University Kiel, Kiel, Germany Nutritional Epidemiology, Department of Nutrition and Food Science, Rheinische Friedrich-Wilhelms-University Bonn, Bonn, Germany. 4. Clinic for Diagnostic Radiology, University Medical Center Schleswig-Holstein, Kiel, Germany. 5. PopGen Biobank, University Medical Center Schleswig-Holstein, Kiel, Germany. 6. Institute of Epidemiology, Christian-Albrechts University Kiel, Kiel, Germany. 7. Institute of Internal Medicine I, Christian-Albrechts University Kiel, Kiel, Germany. 8. Institute of Human Nutrition and Food Science, Christian-Albrechts University Kiel, Kiel, Germany. 9. Institute of Nutritional Medicine, University of Hohenheim, Stuttgart, Germany.
Abstract
BACKGROUND: In prior studies, lifestyle indices were associated with numerous disease end points, but the association with fatty liver disease (FLD), a key correlate of cardiometabolic risk, is unknown. The aim was to investigate associations between a lifestyle index with liver fat content. METHODS: Liver fat was quantified by MRI as liver signal intensity (LSI) in 354 individuals selected from a population-based cohort from Germany. Exposure to favourable lifestyle factors was quantified using an additive score with each factor modelled as a dichotomous trait. Favourable lifestyle factors were defined as waist circumference below 102 (men) or 88 cm (women), physical activity ≥3.5 h/week, never-smoking and a favourable dietary pattern, which was derived to explain liver fat variation. In a cross-sectional study, multivariable adjusted linear and logistic regression was applied to investigate the association between the lifestyle index (range 0-4, exposure) and LSI (modelled as a continuous trait or dichotomised as a FLD indicator variable, respectively). RESULTS: Individuals with four favourable lifestyle factors (n=9%) had lower LSI values (ß -0.40; 95% CI -0.61 to -0.19) and a lower OR (0.09; 95% CI 0.03 to 0.30) for FLD compared with individuals with zero favourable lifestyle factors (n=10%). CONCLUSIONS: A healthy lifestyle pattern was associated with less liver fat. Prospective studies are warranted. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
BACKGROUND: In prior studies, lifestyle indices were associated with numerous disease end points, but the association with fatty liver disease (FLD), a key correlate of cardiometabolic risk, is unknown. The aim was to investigate associations between a lifestyle index with liver fat content. METHODS: Liver fat was quantified by MRI as liver signal intensity (LSI) in 354 individuals selected from a population-based cohort from Germany. Exposure to favourable lifestyle factors was quantified using an additive score with each factor modelled as a dichotomous trait. Favourable lifestyle factors were defined as waist circumference below 102 (men) or 88 cm (women), physical activity ≥3.5 h/week, never-smoking and a favourable dietary pattern, which was derived to explain liver fat variation. In a cross-sectional study, multivariable adjusted linear and logistic regression was applied to investigate the association between the lifestyle index (range 0-4, exposure) and LSI (modelled as a continuous trait or dichotomised as a FLD indicator variable, respectively). RESULTS: Individuals with four favourable lifestyle factors (n=9%) had lower LSI values (ß -0.40; 95% CI -0.61 to -0.19) and a lower OR (0.09; 95% CI 0.03 to 0.30) for FLD compared with individuals with zero favourable lifestyle factors (n=10%). CONCLUSIONS: A healthy lifestyle pattern was associated with less liver fat. Prospective studies are warranted. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
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Keywords:
Epidemiology of chronic non communicable diseases; LIFESTYLE; NUTRITION; OBESITY; PHYSICAL ACTIVITY
Authors: Saman Khalatbari-Soltani; Fumiaki Imamura; Soren Brage; Emanuella De Lucia Rolfe; Simon J Griffin; Nicholas J Wareham; Pedro Marques-Vidal; Nita G Forouhi Journal: BMC Med Date: 2019-01-24 Impact factor: 8.775