BACKGROUND: The aryl hydrocarbon receptor has been shown to be involved in wound healing. OBJECTIVE: The aim of this study was to assess the effect of tryptophan on wound healing in vitro and in a clinical trial. METHODS: The ability of tryptophan and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to increase wound healing was assessed in an in vitro scratch wound model in human keratinocytes. Topical tryptophan and vehicle were assessed for 12 weeks in 51 patients with lower limb ulcers that were resistant to conventional therapies. RESULTS: TCDD 0.1 nM and tryptophan 1 µM increased the rate of scratch recovery in a culture model. Topical tryptophan induced stronger pain relief and faster re-epithelialization than its vehicle in patients with lower limb ulcers. CONCLUSION:Tryptophan shows promising potential as a novel topical treatment for wound healing.
RCT Entities:
BACKGROUND: The aryl hydrocarbon receptor has been shown to be involved in wound healing. OBJECTIVE: The aim of this study was to assess the effect of tryptophan on wound healing in vitro and in a clinical trial. METHODS: The ability of tryptophan and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to increase wound healing was assessed in an in vitro scratch wound model in human keratinocytes. Topical tryptophan and vehicle were assessed for 12 weeks in 51 patients with lower limb ulcers that were resistant to conventional therapies. RESULTS:TCDD 0.1 nM and tryptophan 1 µM increased the rate of scratch recovery in a culture model. Topical tryptophan induced stronger pain relief and faster re-epithelialization than its vehicle in patients with lower limb ulcers. CONCLUSION:Tryptophan shows promising potential as a novel topical treatment for wound healing.
Authors: Jose J Limon; Jie Tang; Dalin Li; Andrea J Wolf; Kathrin S Michelsen; Vince Funari; Matthew Gargus; Christopher Nguyen; Purnima Sharma; Viviana I Maymi; Iliyan D Iliev; Joseph H Skalski; Jordan Brown; Carol Landers; James Borneman; Jonathan Braun; Stephan R Targan; Dermot P B McGovern; David M Underhill Journal: Cell Host Microbe Date: 2019-03-05 Impact factor: 21.023
Authors: Kenneth S Brandenburg; Diego F Calderon; Patricia R Kierski; Amanda L Brown; Nihar M Shah; Nicholas L Abbott; Michael J Schurr; Christopher J Murphy; Jonathan F McAnulty; Charles J Czuprynski Journal: Wound Repair Regen Date: 2015-11-04 Impact factor: 3.617