Literature DB >> 25764221

A matter of access. Nucleosome disassembly from gene promoters is the central goal of transcriptional activators.

Zheng Hu1, Kaifu Chen, Wei Li, Jessica K Tyler.   

Abstract

The mechanism whereby transcriptional activators facilitate transcription activation has been debated. Our recent genome-wide profiling of gene expression during aging, where nucleosomes are depleted, indicates that the function of seemingly all transcriptional activators is to trigger nucleosome disassembly from promoters to allow the general transcription machinery access to the DNA.

Keywords:  aging; histones; nucleosomes; transcription; yeast

Mesh：

Substances：

Year:  2014        PMID： 25764221      PMCID： PMC4215176          DOI： 10.4161/trns.29355

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  22 in total

1.  Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast.

Authors:  J J Wyrick; F C Holstege; E G Jennings; H C Causton; D Shore; M Grunstein; E S Lander; R A Young
Journal:  Nature       Date:  1999-11-25       Impact factor: 49.962

2.  Histones are first hyperacetylated and then lose contact with the activated PHO5 promoter.

Authors:  Hans Reinke; Wolfram Hörz
Journal:  Mol Cell       Date:  2003-06       Impact factor: 17.970

3.  Nucleosome core displacement in vitro via a metastable transcription factor-nucleosome complex.

Authors:  J L Workman; R E Kingston
Journal:  Science       Date:  1992-12-11       Impact factor: 47.728

4.  Nucleosome loss activates yeast downstream promoters in vivo.

Authors:  M Han; M Grunstein
Journal:  Cell       Date:  1988-12-23       Impact factor: 41.582

5.  Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones.

Authors:  Y Lorch; J W LaPointe; R D Kornberg
Journal:  Cell       Date:  1987-04-24       Impact factor: 41.582

6.  The presence of nucleosomes on a DNA template prevents initiation by RNA polymerase II in vitro.

Authors:  J A Knezetic; D S Luse
Journal:  Cell       Date:  1986-04-11       Impact factor: 41.582

7.  Tetrahymena histone acetyltransferase A: a homolog to yeast Gcn5p linking histone acetylation to gene activation.

Authors:  J E Brownell; J Zhou; T Ranalli; R Kobayashi; D G Edmondson; S Y Roth; C D Allis
Journal:  Cell       Date:  1996-03-22       Impact factor: 41.582

8.  ATP-dependent nucleosome reconfiguration and transcriptional activation from preassembled chromatin templates.

Authors:  M J Pazin; R T Kamakaka; J T Kadonaga
Journal:  Science       Date:  1994-12-23       Impact factor: 47.728

9.  Transcription elongation factors repress transcription initiation from cryptic sites.

Authors:  Craig D Kaplan; Lisa Laprade; Fred Winston
Journal:  Science       Date:  2003-08-22       Impact factor: 47.728

10.  Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes.

Authors:  Melissa W Adkins; Susan R Howar; Jessica K Tyler
Journal:  Mol Cell       Date:  2004-06-04       Impact factor: 17.970
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  1 in total

1.  Nucleolar asymmetry and the importance of septin integrity upon cell cycle arrest.

Authors:  Urvashi Rai; Fadi Najm; Alan M Tartakoff
Journal:  PLoS One       Date:  2017-03-24       Impact factor: 3.240
  1 in total

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