Serdar Saraç1, Aytaç Atamer2, Yildiz Atamer1, Ahmet Selçuk Can1, Aslan Bilici3, İbrahim Taçyildiz4, Yüksel Koçyiğit5, Necati Yenice6. 1. Termal Vocational School, Yalova University, Yalova, Turkey. 2. Termal Vocational School, Yalova University, Yalova, Turkey aytacatamer@gmail.com. 3. Department of Radiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey. 4. Department of General Surgery, Faculty of Medicine, Dicle University, Diyarbakir, Turkey. 5. Department of Physiology, Faculty of Medicine, Dicle University, Diyarbakir, Turkey. 6. Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Harran University, Urfa, Turkey.
Abstract
OBJECTIVE: To determine the relationships between serum leptin and levels of lipoprotein(a) [Lp(a)], apolipoprotein A-1 (ApoA-1) and apolipoprotein B (ApoB) in patients with cholelithiasis. METHODS: Patients with ultrasound-confirmed cholelithiasis and controls frequency-matched for age, sex, body mass index, fasting blood glucose and haemoglobin A1c levels were recruited. Fasting blood samples from all study participants were assayed for glucose, haemoglobin A1c, total cholesterol, high density lipoprotein-cholesterol (HDL-C) and triglyceride. Serum Lp(a), ApoA-1 and ApoB levels were measured using nephelometric assays; serum leptin was measured using an enzyme-linked immunosorbent assay. RESULTS: A total of 90 patients with cholelithiasis and 50 controls were included in the study. Serum levels of leptin, Lp(a), total cholesterol, triglyceride and ApoB were significantly increased, and levels of ApoA-1 and HDL-C were significantly decreased, in patients with cholelithiasis compared with controls. Serum leptin in patients with cholelithiasis were significantly positively correlated with Lp(a) and ApoB and negatively correlated with ApoA-1. CONCLUSIONS: Patients with cholelithiasis have higher leptin levels and an altered lipoprotein profile compared with controls, with increased leptin levels being associated with increased Lp(a) and ApoB levels, and decreased ApoA-1 levels, in those with cholelithiasis.
OBJECTIVE: To determine the relationships between serum leptin and levels of lipoprotein(a) [Lp(a)], apolipoprotein A-1 (ApoA-1) and apolipoprotein B (ApoB) in patients with cholelithiasis. METHODS:Patients with ultrasound-confirmed cholelithiasis and controls frequency-matched for age, sex, body mass index, fasting blood glucose and haemoglobin A1c levels were recruited. Fasting blood samples from all study participants were assayed for glucose, haemoglobin A1c, total cholesterol, high density lipoprotein-cholesterol (HDL-C) and triglyceride. Serum Lp(a), ApoA-1 and ApoB levels were measured using nephelometric assays; serum leptin was measured using an enzyme-linked immunosorbent assay. RESULTS: A total of 90 patients with cholelithiasis and 50 controls were included in the study. Serum levels of leptin, Lp(a), total cholesterol, triglyceride and ApoB were significantly increased, and levels of ApoA-1 and HDL-C were significantly decreased, in patients with cholelithiasis compared with controls. Serum leptin in patients with cholelithiasis were significantly positively correlated with Lp(a) and ApoB and negatively correlated with ApoA-1. CONCLUSIONS:Patients with cholelithiasis have higher leptin levels and an altered lipoprotein profile compared with controls, with increased leptin levels being associated with increased Lp(a) and ApoB levels, and decreased ApoA-1 levels, in those with cholelithiasis.
Authors: Anca D Petrescu; Stephanie Grant; Elaina Williams; Su Yeon An; Nikhil Seth; Mark Shell; Tyson Amundsen; Christopher Tan; Yusra Nadeem; Matthew Tjahja; Lancaster Weld; Christopher S Chu; Julie Venter; Gabriel Frampton; Matthew McMillin; Sharon DeMorrow Journal: Am J Pathol Date: 2021-12-08 Impact factor: 4.307