BACKGROUND: Filgrastim biosimilars have recently been introduced into clinical practice. To date biosimilars have demonstrated comparable efficacy and safety as the originator in chemotherapy-induced neutropenia. Published experience in engraftment after autologous stem cell transplantation (ASCT) is limited and concerns relatively few patients. MATERIALS AND METHODS: With the aim of assessing the efficacy and the safety of filgrastim biosimilars in post-ASCT bone marrow recovery, we conducted a single institution, retrospective study in 56 lymphoma and myeloma patients who received filgrastim biosimilars (Tevagrastim(®) and Zarzio(®)) at standard doses from day 5. We compared our results with recently published data on the originator. A cost analysis of each biosimilar was performed. RESULTS: Neutrophil counts recovered in 55 patients. The median number of filgrastim biosimilar vials injected was seven per patient. The median time to neutrophil and platelet recovery was 10 and 12 days, respectively. Twenty-six patients had febrile neutropenia, in half of whom the agent involved was identified. In the cost analysis, the use of Tevagrastim(®) and Zarzio(®) was associated with cost reductions of 56% and of 86%, respectively. DISCUSSION: Despite differences in CD34+ cell counts and time of starting filgrastim, our results in terms of time to engraftment and median number of vials injected are similar to published data. Comparing our results by single conditioning regimen to recent literature data, the time to engraftment and duration of hospitalisation were equivalent. Significant differences were observed in the incidence of febrile neutropenia, perhaps due to different preventive and prophylactic protocols for infections. Although prospective studies should be performed to confirm our results, filgrastim biosimilars were found to be effective and safe in engraftment after ASCT.
BACKGROUND: Filgrastim biosimilars have recently been introduced into clinical practice. To date biosimilars have demonstrated comparable efficacy and safety as the originator in chemotherapy-induced neutropenia. Published experience in engraftment after autologous stem cell transplantation (ASCT) is limited and concerns relatively few patients. MATERIALS AND METHODS: With the aim of assessing the efficacy and the safety of filgrastim biosimilars in post-ASCT bone marrow recovery, we conducted a single institution, retrospective study in 56 lymphoma and myelomapatients who received filgrastim biosimilars (Tevagrastim(®) and Zarzio(®)) at standard doses from day 5. We compared our results with recently published data on the originator. A cost analysis of each biosimilar was performed. RESULTS: Neutrophil counts recovered in 55 patients. The median number of filgrastim biosimilar vials injected was seven per patient. The median time to neutrophil and platelet recovery was 10 and 12 days, respectively. Twenty-six patients had febrile neutropenia, in half of whom the agent involved was identified. In the cost analysis, the use of Tevagrastim(®) and Zarzio(®) was associated with cost reductions of 56% and of 86%, respectively. DISCUSSION: Despite differences in CD34+ cell counts and time of starting filgrastim, our results in terms of time to engraftment and median number of vials injected are similar to published data. Comparing our results by single conditioning regimen to recent literature data, the time to engraftment and duration of hospitalisation were equivalent. Significant differences were observed in the incidence of febrile neutropenia, perhaps due to different preventive and prophylactic protocols for infections. Although prospective studies should be performed to confirm our results, filgrastim biosimilars were found to be effective and safe in engraftment after ASCT.
Authors: J-C Ianotto; A Tempescul; X Yan; P Delepine; R Le Calloch; E Hardy; J-R Eveillard; N Mugnier; C Berthou; G Guillerm Journal: Bone Marrow Transplant Date: 2011-09-26 Impact factor: 5.483
Authors: M S Aapro; D A Cameron; R Pettengell; J Bohlius; J Crawford; M Ellis; N Kearney; G H Lyman; V C Tjan-Heijnen; J Walewski; D C Weber; C Zielinski Journal: Eur J Cancer Date: 2006-06-05 Impact factor: 9.162
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Authors: Luisa Giaccone; Lucia Brunello; Jaime Suarez Londono; Matilde Scaldaferri; Marco Cerrano; Valter Redoglia; Paola Omedè; Giuseppe Lia; Massimo Massaia; Dario Ferrero; Federica Cavallo; Sara Bringhen; Sarah Leone; Francesco Cattel; Tiziana Francisci; Valter Tassi; Andrea Evangelista; Mario Boccadoro; Benedetto Bruno Journal: Bone Marrow Transplant Date: 2021-11-30 Impact factor: 5.483
Authors: Hyun Jin Oh; So Yeon Hong; Young Mi Jeong; Kyung Suk Choi; Eunsook Lee; Euni Lee; Yu Jung Kim; Soo-Mee Bang Journal: Blood Res Date: 2020-09-30
Authors: M Martino; R M Lemoli; C Girmenia; L Castagna; B Bruno; F Cavallo; M Offidani; I Scortechini; M Montanari; G Milone; L Postacchini; A Olivieri Journal: Bone Marrow Transplant Date: 2016-04-04 Impact factor: 5.483
Authors: Derek S Park; Afua A Akuffo; David E Muench; H Leighton Grimes; Pearlie K Epling-Burnette; Philip K Maini; Alexander R A Anderson; Michael B Bonsall Journal: PLoS Comput Biol Date: 2019-04-26 Impact factor: 4.475
Authors: Sadik Husian; Preethi Jeyaraman; S K Gupta; Reeta Rai; Sangeeta Pathak; Nitin Dayal; Rahul Naithani Journal: South Asian J Cancer Date: 2021-09-04