Flavia Prodam1, Marta Roccio2, Letizia Trovato3, Roberta Ricotti4, Stefania Moia4, Enza Giglione4, Antonella Petri5, Gillian E Walker4, Simonetta Bellone5, Gianni Bona6. 1. 1] Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy [2] Endocrinology, Department of Clinical & Experimental Medicine, University of Piemonte Orientale, Novara, Italy [3] Interdisciplinary Center for Obesity Study (ICOS), University of Piemonte Orientale, Novara, Italy. 2. 1] Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy [2] Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale, Novara, Italy. 3. Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Torino, Torino, Italy. 4. Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy. 5. 1] Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy [2] Interdisciplinary Center for Obesity Study (ICOS), University of Piemonte Orientale, Novara, Italy. 6. 1] Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy [2] Interdisciplinary Center for Obesity Study (ICOS), University of Piemonte Orientale, Novara, Italy [3] Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Piemonte Orientale, Novara, Italy.
Abstract
BACKGROUND: Nutrition and growth in early postnatal life have a role in future diseases. Our aim was to investigate adiponectin oligomers in adequate-for-gestational-age obese children with respect to type and duration of feeding in the first year of life. METHODS: Adiponectin oligomers and cardiometabolic risk factors were measured in 113 adequate-for-gestational-age obese children, divided into group A (prolonged breast feeding, >6 mo), group B (short breast feeding, 1-6 mo), and group C (formula feeding from birth). RESULTS: All the parameters were similar among the groups. Adiponectin oligomers did not correlate with gestational age, months of breast feeding, and time of weaning. Total and high-molecular weight adiponectin were differently distributed across gender and pubertal stages (P < 0.02), being lower in males from the start of puberty. Prepregnancy BMI and at the end of the pregnancy were negatively associated (P < 0.04) with total and medium-molecular weight adiponectin in female and male offspring, respectively. CONCLUSIONS: Adiponectin oligomers and metabolic characteristics are similarly distributed in adequate-for-gestational-age obese children, irrespective of the type and duration of the feeding in the first year of life. Gender and mother's BMI in pregnancy are contributors to adiponectin regulation. Further studies will explain whether breastfeeding protects against metabolic impairment later in life.
BACKGROUND: Nutrition and growth in early postnatal life have a role in future diseases. Our aim was to investigate adiponectin oligomers in adequate-for-gestational-age obesechildren with respect to type and duration of feeding in the first year of life. METHODS:Adiponectin oligomers and cardiometabolic risk factors were measured in 113 adequate-for-gestational-age obesechildren, divided into group A (prolonged breast feeding, >6 mo), group B (short breast feeding, 1-6 mo), and group C (formula feeding from birth). RESULTS: All the parameters were similar among the groups. Adiponectin oligomers did not correlate with gestational age, months of breast feeding, and time of weaning. Total and high-molecular weight adiponectin were differently distributed across gender and pubertal stages (P < 0.02), being lower in males from the start of puberty. Prepregnancy BMI and at the end of the pregnancy were negatively associated (P < 0.04) with total and medium-molecular weight adiponectin in female and male offspring, respectively. CONCLUSIONS:Adiponectin oligomers and metabolic characteristics are similarly distributed in adequate-for-gestational-age obesechildren, irrespective of the type and duration of the feeding in the first year of life. Gender and mother's BMI in pregnancy are contributors to adiponectin regulation. Further studies will explain whether breastfeeding protects against metabolic impairment later in life.
Authors: Nicole L Mihalopoulos; Brittney M Urban; Julie M Metos; Alfred H Balch; Paul C Young; Kristine C Jordan Journal: South Med J Date: 2017-05 Impact factor: 0.954