Literature DB >> 25759332

Multipurpose prevention technologies: the future of HIV and STI protection.

José A Fernández-Romero1, Carolyn Deal2, Betsy C Herold3, John Schiller4, Dorothy Patton5, Thomas Zydowsky1, Joe Romano6, Christopher D Petro3, Manjulaa Narasimhan7.   

Abstract

Every day, more than 1 million people are newly infected with sexually transmitted infections (STIs) that can lead to morbidity, mortality, and an increased risk of human immunodeficiency virus (HIV) acquisition. Existing prevention and management strategies, including behavior change, condom promotion, and therapy have not reduced the global incidence and prevalence, pointing to the need for novel innovative strategies. This review summarizes important issues raised during a satellite session at the first HIV Research for Prevention (R4P) conference, held in Cape Town, on October 31, 2014. We explore key STIs that are challenging public health today, new biomedical prevention approaches including multipurpose prevention technologies (MPTs), and the scientific and regulatory hurdles that must be overcome to make combination prevention tools a reality.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  HIV; HPV; HSV-2; STI; Trichomonas vaginalis; multipurpose prevention technologies

Mesh：

Year:  2015        PMID： 25759332      PMCID： PMC4490993          DOI： 10.1016/j.tim.2015.02.006

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  57 in total

1.  Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.

Authors:  Quarraisha Abdool Karim; Salim S Abdool Karim; Janet A Frohlich; Anneke C Grobler; Cheryl Baxter; Leila E Mansoor; Ayesha B M Kharsany; Sengeziwe Sibeko; Koleka P Mlisana; Zaheen Omar; Tanuja N Gengiah; Silvia Maarschalk; Natasha Arulappan; Mukelisiwe Mlotshwa; Lynn Morris; Douglas Taylor
Journal:  Science       Date:  2010-07-19       Impact factor: 47.728

2.  Ensuring successful development and introduction of multipurpose prevention technologies through an innovative partnership approach.

Authors:  B Young Holt; J Romano; J Manning; A Hemmerling; W Shields; L Vyda; M Lusti-Narasimhan
Journal:  BJOG       Date:  2014-10       Impact factor: 6.531

3.  Efficacy results of a trial of a herpes simplex vaccine.

Authors:  Robert B Belshe; Peter A Leone; David I Bernstein; Anna Wald; Myron J Levin; Jack T Stapleton; Iris Gorfinkel; Rhoda L Ashley Morrow; Marian G Ewell; Abbie Stokes-Riner; Gary Dubin; Thomas C Heineman; Joann M Schulte; Carolyn D Deal
Journal:  N Engl J Med       Date:  2012-01-05       Impact factor: 91.245

4.  In vivo mechanisms of vaccine-induced protection against HPV infection.

Authors:  Patricia M Day; Rhonda C Kines; Cynthia D Thompson; Subhashini Jagu; Richard B Roden; Douglas R Lowy; John T Schiller
Journal:  Cell Host Microbe       Date:  2010-09-16       Impact factor: 21.023

5.  Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.

Authors:  Jared M Baeten; Deborah Donnell; Patrick Ndase; Nelly R Mugo; James D Campbell; Jonathan Wangisi; Jordan W Tappero; Elizabeth A Bukusi; Craig R Cohen; Elly Katabira; Allan Ronald; Elioda Tumwesigye; Edwin Were; Kenneth H Fife; James Kiarie; Carey Farquhar; Grace John-Stewart; Aloysious Kakia; Josephine Odoyo; Akasiima Mucunguzi; Edith Nakku-Joloba; Rogers Twesigye; Kenneth Ngure; Cosmas Apaka; Harrison Tamooh; Fridah Gabona; Andrew Mujugira; Dana Panteleeff; Katherine K Thomas; Lara Kidoguchi; Meighan Krows; Jennifer Revall; Susan Morrison; Harald Haugen; Mira Emmanuel-Ogier; Lisa Ondrejcek; Robert W Coombs; Lisa Frenkel; Craig Hendrix; Namandjé N Bumpus; David Bangsberg; Jessica E Haberer; Wendy S Stevens; Jairam R Lingappa; Connie Celum
Journal:  N Engl J Med       Date:  2012-07-11       Impact factor: 91.245

6.  The initial steps leading to papillomavirus infection occur on the basement membrane prior to cell surface binding.

Authors:  Rhonda C Kines; Cynthia D Thompson; Douglas R Lowy; John T Schiller; Patricia M Day
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-17       Impact factor: 11.205

Review 7.  Cervical and anal HPV infections in HIV positive women and men.

Authors:  Silvia de Sanjosé; Joel Palefsky
Journal:  Virus Res       Date:  2002-11       Impact factor: 3.303

8.  Once-daily valacyclovir to reduce the risk of transmission of genital herpes.

Authors:  Lawrence Corey; Anna Wald; Raj Patel; Stephen L Sacks; Stephen K Tyring; Terri Warren; John M Douglas; Jorma Paavonen; R Ashley Morrow; Karl R Beutner; Leonid S Stratchounsky; Gregory Mertz; Oliver N Keene; Helen A Watson; Dereck Tait; Mauricio Vargas-Cortes
Journal:  N Engl J Med       Date:  2004-01-01       Impact factor: 91.245

9.  Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan.

Authors:  Jeffrey N Roberts; Christopher B Buck; Cynthia D Thompson; Rhonda Kines; Marcelino Bernardo; Peter L Choyke; Douglas R Lowy; John T Schiller
Journal:  Nat Med       Date:  2007-07-01       Impact factor: 53.440

10.  Treatment of sexually transmitted infections for HIV prevention: end of the road or new beginning?

Authors:  Richard Hayes; Deborah Watson-Jones; Connie Celum; Janneke van de Wijgert; Judith Wasserheit
Journal:  AIDS       Date:  2010-10       Impact factor: 4.177
View more
  29 in total

1.  Contraceptive Practice in Sub-Saharan Africa.

Authors:  Amy O Tsui; Win Brown; Qingfeng Li
Journal:  Popul Dev Rev       Date:  2017-03-31

2.  Gene expression patterns in transgenic mouse models of hypertrophic cardiomyopathy caused by mutations in myosin regulatory light chain.

Authors:  Wenrui Huang; Katarzyna Kazmierczak; Zhiqun Zhou; Vanessa Aguiar-Pulido; Giri Narasimhan; Danuta Szczesna-Cordary
Journal:  Arch Biochem Biophys       Date:  2016-02-22       Impact factor: 4.013

3.  Receptive anal sex contributes substantially to heterosexually acquired HIV infections among at-risk women in twenty US cities: Results from a modelling analysis.

Authors:  Jocelyn Elmes; Romain Silhol; Kristen L Hess; Lukyn M Gedge; Ashley Nordsletten; Roisin Staunton; Peter Anton; Barbara Shacklett; Ian McGowan; Que Dang; Adaora A Adimora; Dobromir T Dimitrov; Sevgi Aral; Senad Handanagic; Gabriela Paz-Bailey; Marie-Claude Boily
Journal:  Am J Reprod Immunol       Date:  2020-06-09       Impact factor: 3.886

4.  Screening for Sexually Transmitted Infections in Antenatal Care Is Especially Important Among HIV-Infected Women.

Authors:  Sten H Vermund
Journal:  Sex Transm Dis       Date:  2015-10       Impact factor: 2.830

5.  MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa.

Authors:  Giulia Calenda; Guillermo Villegas; Patrick Barnable; Claudia Litterst; Keith Levendosky; Agegnehu Gettie; Michael L Cooney; James Blanchard; José A Fernández-Romero; Thomas M Zydowsky; Natalia Teleshova
Journal:  J Acquir Immune Defic Syndr       Date:  2017-03-01       Impact factor: 3.731

6.  Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea.

Authors:  Ryszard A Zielke; Igor H Wierzbicki; Benjamin I Baarda; Philip R Gafken; Olusegun O Soge; King K Holmes; Ann E Jerse; Magnus Unemo; Aleksandra E Sikora
Journal:  Mol Cell Proteomics       Date:  2016-05-02       Impact factor: 5.911

Review 7.  Enzymatic Transition States and Drug Design.

Authors:  Vern L Schramm
Journal:  Chem Rev       Date:  2018-10-18       Impact factor: 60.622

8.  In Vitro Exposure to PC-1005 and Cervicovaginal Lavage Fluid from Women Vaginally Administered PC-1005 Inhibits HIV-1 and HSV-2 Infection in Human Cervical Mucosa.

Authors:  Guillermo Villegas; Giulia Calenda; Shimin Zhang; Olga Mizenina; Kyle Kleinbeck; Michael L Cooney; Craig J Hoesley; George W Creasy; Barbara Friedland; José A Fernández-Romero; Thomas M Zydowsky; Natalia Teleshova
Journal:  Antimicrob Agents Chemother       Date:  2016-08-22       Impact factor: 5.191

9.  A Quantitative Disintegration Method for Polymeric Films.

Authors:  Sheila Grab; Lisa C Rohan
Journal:  J Pharm Innov       Date:  2018-05-11       Impact factor: 2.750

10.  Reproductive Life Goals: A Systematic Review of Pregnancy Planning Intentions, Needs, and Interventions Among Women Involved in U.S. Criminal Justice Systems.

Authors:  Emily Hoff; Zoe M Adams; Alyssa Grimshaw; Dawn A Goddard-Eckrich; Anindita Dasgupta; Sangini S Sheth; Jaimie P Meyer
Journal:  J Womens Health (Larchmt)       Date:  2020-06-23       Impact factor: 2.681
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.