Literature DB >> 25757426

VHR/DUSP3 phosphatase: structure, function and regulation.

Karolina Pavic1, Guangyou Duan1, Maja Köhn1.   

Abstract

Vaccinia H1-related (VHR) phosphatase, also known as dual-specificity phosphatase (DUSP) 3, is a small member of the DUSP (also called DSP) family of phosphatases. VHR has a preference for phospho-tyrosine substrates, and has important roles in cellular signaling ranging from cell-cycle regulation and the DNA damage response to MAPK signaling, platelet activation and angiogenesis. VHR/DUSP3 has been implicated in several human cancers, where its tumor-suppressing and -promoting properties have been described. We give a detailed overview of VHR/DUSP3 phosphatase and compare it with its most closely related phosphatases DUSP13B, DUSP26 and DUSP27.
© 2015 The Authors. FEBS Journal published by John Wiley & Sons Ltd on behalf of FEBS.

Entities:  

Keywords:  DUSP13B; DUSP26; DUSP27; MAPK signaling; VHR/DUSP3 inhibitors; Vaccinia H1-related phosphatase; cancer; cell-cycle progression; dual specificity phosphatases; protein phosphatases

Mesh：

Substances：

Year:  2015        PMID： 25757426     DOI： 10.1111/febs.13263

Source DB:  PubMed          Journal:  FEBS J        ISSN： 1742-464X            Impact factor:   5.542


  9 in total

1.  Protein tyrosine phosphatase 1B inhibitory properties of seco-cucurbitane triterpenes obtained from fruiting bodies of Russula lepida.

Authors:  Wilmar Maarisit; Hiroyuki Yamazaki; Syu-Ichi Kanno; Ayako Tomizawa; Jong-Soo Lee; Michio Namikoshi
Journal:  J Nat Med       Date:  2016-11-19       Impact factor: 2.343

Review 2.  Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases.

Authors:  Zhi-Hong Yu; Zhong-Yin Zhang
Journal:  Chem Rev       Date:  2017-05-25       Impact factor: 60.622

3.  Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration.

Authors:  Y-R Chen; H-C Chou; C-H Yang; H-Y Chen; Y-W Liu; T-Y Lin; C-L Yeh; W-T Chao; H-H Tsou; H-C Chuang; T-H Tan
Journal:  Oncogene       Date:  2017-07-31       Impact factor: 9.867

4.  Allosteric Impact of the Variable Insert Loop in Vaccinia H1-Related (VHR) Phosphatase.

Authors:  Victor A Beaumont; Krystle Reiss; Zexing Qu; Brandon Allen; Victor S Batista; J Patrick Loria
Journal:  Biochemistry       Date:  2020-05-06       Impact factor: 3.162

Review 5.  Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.

Authors:  Lutz Tautz; Yotis A Senis; Cécile Oury; Souad Rahmouni
Journal:  Bioorg Med Chem       Date:  2015-04-04       Impact factor: 3.641

6.  Dusp26 phosphatase regulates mitochondrial respiration and oxidative stress and protects neuronal cell death.

Authors:  Binnur Eroglu; Xiongjie Jin; Sadiki Deane; Bahadır Öztürk; Owen A Ross; Demetrius Moskophidis; Nahid F Mivechi
Journal:  Cell Mol Life Sci       Date:  2022-03-21       Impact factor: 9.261

7.  Regulation of signal transducer and activator of transcription 3 activation by dual-specificity phosphatase 3.

Authors:  Ba Reum Kim; Jain Ha; Eunjeong Kang; Sayeon Cho
Journal:  BMB Rep       Date:  2020-06       Impact factor: 4.778

Review 8.  Structure-Activity Relationship of Cytotoxic Natural Products from Indonesian Marine Sponges.

Authors:  Jonathan A Panggabean; Sya'ban P Adiguna; Tutik Murniasih; Siti I Rahmawati; Asep Bayu; Masteria Y Putra
Journal:  Rev Bras Farmacogn       Date:  2022-01-07       Impact factor: 2.464

9.  Exosomal miR-1246 from glioma patient body fluids drives the differentiation and activation of myeloid-derived suppressor cells.

Authors:  Wei Qiu; Xiaofan Guo; Boyan Li; Jian Wang; Yanhua Qi; Zihang Chen; Rongrong Zhao; Lin Deng; Mingyu Qian; Shaobo Wang; Zongpu Zhang; Qindong Guo; Shouji Zhang; Ziwen Pan; Shulin Zhao; Hao Xue; Gang Li
Journal:  Mol Ther       Date:  2021-07-02       Impact factor: 11.454
  9 in total

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