Giorgio Treglia1, Ramin Sadeghi2, Camilla Schalin-Jäntti3, Carmelo Caldarella4, Luca Ceriani1, Luca Giovanella1, David W Eisele. 1. Department of Nuclear Medicine, PET/CT and Thyroid Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland. 2. Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 3. Division of Endocrinology, Abdominal Center, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. 4. Institute of Nuclear Medicine, Catholic University, Rome, Italy.
Abstract
BACKGROUND: Parathyroid scintigraphy using (99m) Tc-MIBI single photon emission computed tomography (SPECT)/CT has been proposed as one of the most accurate localization techniques in patients with primary hyperparathyroidism (PHPT). The purpose of this review was to meta-analyze published data on the detection rate of (99m) Tc-MIBI SPECT/CT in the preoperative planning of patients with PHPT. METHODS: A comprehensive literature search of studies published through June 2014 was performed. The pooled detection rate of this scintigraphic method including 95% confidence intervals (95% CIs) was calculated on a per patient-based and on a per lesion-based analysis by using a random effects model. RESULTS: Twenty-three articles including 1236 patients with PHPT were selected. The pooled detection rate of (99m) Tc-MIBI SPECT/CT in the preoperative planning of patients with PHPT was 88% (95% CI = 84% to 92%) and 88% (95% CI = 82% to 92%) on a per patient-based and per lesion-based analysis, respectively. CONCLUSION: The (99m) Tc-MIBI SPECT/CT has high detection rate for hyperfunctioning parathyroid glands in patients with PHPT.
BACKGROUND: Parathyroid scintigraphy using (99m) Tc-MIBI single photon emission computed tomography (SPECT)/CT has been proposed as one of the most accurate localization techniques in patients with primary hyperparathyroidism (PHPT). The purpose of this review was to meta-analyze published data on the detection rate of (99m) Tc-MIBI SPECT/CT in the preoperative planning of patients with PHPT. METHODS: A comprehensive literature search of studies published through June 2014 was performed. The pooled detection rate of this scintigraphic method including 95% confidence intervals (95% CIs) was calculated on a per patient-based and on a per lesion-based analysis by using a random effects model. RESULTS: Twenty-three articles including 1236 patients with PHPT were selected. The pooled detection rate of (99m) Tc-MIBI SPECT/CT in the preoperative planning of patients with PHPT was 88% (95% CI = 84% to 92%) and 88% (95% CI = 82% to 92%) on a per patient-based and per lesion-based analysis, respectively. CONCLUSION: The (99m) Tc-MIBI SPECT/CT has high detection rate for hyperfunctioning parathyroid glands in patients with PHPT.
Authors: Arnoldo Piccardo; P Trimboli; M Rutigliani; M Puntoni; L Foppiani; L Bacigalupo; Anna Crescenzi; G Bottoni; G Treglia; F Paparo; P Del Monte; M Lanata; G Paone; G Ferrarazzo; U Catrambone; A Arlandini; L Ceriani; M Cabria; L Giovanella Journal: Eur J Nucl Med Mol Imaging Date: 2018-09-15 Impact factor: 9.236
Authors: Giorgio Treglia; Arnoldo Piccardo; Alessio Imperiale; Klaus Strobel; Philipp A Kaufmann; John O Prior; Luca Giovanella Journal: Eur J Nucl Med Mol Imaging Date: 2018-08-09 Impact factor: 9.236
Authors: Serena Grimaldi; Jacques Young; Peter Kamenicky; Dana Hartl; Marie Terroir; Sophie Leboulleux; Amandine Berdelou; Julien Hadoux; Segolene Hescot; Hervé Remy; Eric Baudin; Martin Schlumberger; Désirée Deandreis Journal: Eur J Nucl Med Mol Imaging Date: 2018-04-22 Impact factor: 9.236
Authors: H Anderson; K H Lim; D Simpson; S Gull; R Oprean; F Lee; C Kakos; I T Cvasciuc Journal: Acta Endocrinol (Buchar) Date: 2021 Jul-Sep Impact factor: 0.877