OBJECTIVES: The aim was to evaluate the clinical significance and prognostic value of tissue miR-150 expression in non-small cell lung cancer (NSCLC) patients. MATERIALS AND METHODS: Quantitative real-time PCR was used to analyze the expression of miR-150. Overall survival (OS) was estimated using the Kaplan-Meier method, and the differences in survival were compared using the log-rank test. A Cox proportional hazards model was used for multivariate analysis. RESULTS: Mean miR-150 levels were significantly higher in NSCLC tissues compared with matched non-cancerous tissues (4.07 ± 2.33 vs. 1.00 ± 0.46, P < 0.0001). The level of miR-150 in NSCLC was strongly correlated with lymph node metastasis (P = 0.04), distant metastasis (P = 0.01) and clinical TNM stage (P = 0.02). Kaplan-Meier analysis showed that the cumulative 5-year OS rate was 40.8% in the high expression group, and 69.2% in the low expression group. The log-rank test showed that the OS rate of patients with high miR-150 expression was significantly poorer than that of the remaining cases (P = 0.007). CONCLUSION: Our data indicated that overexpression of miR-150 in NSCLC tissues has prognostic value.
OBJECTIVES: The aim was to evaluate the clinical significance and prognostic value of tissue miR-150 expression in non-small cell lung cancer (NSCLC) patients. MATERIALS AND METHODS: Quantitative real-time PCR was used to analyze the expression of miR-150. Overall survival (OS) was estimated using the Kaplan-Meier method, and the differences in survival were compared using the log-rank test. A Cox proportional hazards model was used for multivariate analysis. RESULTS: Mean miR-150 levels were significantly higher in NSCLC tissues compared with matched non-cancerous tissues (4.07 ± 2.33 vs. 1.00 ± 0.46, P < 0.0001). The level of miR-150 in NSCLC was strongly correlated with lymph node metastasis (P = 0.04), distant metastasis (P = 0.01) and clinical TNM stage (P = 0.02). Kaplan-Meier analysis showed that the cumulative 5-year OS rate was 40.8% in the high expression group, and 69.2% in the low expression group. The log-rank test showed that the OS rate of patients with high miR-150 expression was significantly poorer than that of the remaining cases (P = 0.007). CONCLUSION: Our data indicated that overexpression of miR-150 in NSCLC tissues has prognostic value.
Authors: Tsung-Cheng Chang; Duonan Yu; Yun-Sil Lee; Erik A Wentzel; Dan E Arking; Kristin M West; Chi V Dang; Andrei Thomas-Tikhonenko; Joshua T Mendell Journal: Nat Genet Date: 2007-12-09 Impact factor: 38.330
Authors: Ivan A Zaporozhchenko; Evgeny S Morozkin; Anastasia A Ponomaryova; Elena Y Rykova; Nadezhda V Cherdyntseva; Aleksandr A Zheravin; Oksana A Pashkovskaya; Evgeny A Pokushalov; Valentin V Vlassov; Pavel P Laktionov Journal: Sci Rep Date: 2018-04-20 Impact factor: 4.379
Authors: F Du; P Yuan; Z T Zhao; Z Yang; T Wang; J D Zhao; Y Luo; F Ma; J Y Wang; Y Fan; R G Cai; P Zhang; Q Li; Y M Song; B H Xu Journal: Sci Rep Date: 2016-09-21 Impact factor: 4.379