Literature DB >> 25755740

HMGB1-induced autophagy in Schwann cells promotes neuroblastoma proliferation.

Yongsheng Liu1, Laijun Song2.   

Abstract

Neuroblastoma inflicts mostly on children, and the pathogenesis remains elusive. Clinical diagnosis and therapeutic approaches are still on the incipient stage, so further understanding of the molecular and cellular mechanisms of the disease is necessary. Inflammation has been commonly regarded as a hallmark in tumorigenesis and development, and we identified a new inflammatory factor, HMGB1, is considerably increased in neuroblastoma. Our study shows that HMGB1 induces autophagy in Schwann cells through activation of TLR4, and knockdown of TLR4 obviates the HMGB1-induced autophagy. The HMGB1-induced autophagy is through classical pathway, as deficiency of Beclin 1 deprived autophagy in Schwann cells. Coculture of neuroblastoma with Schwann cells pretreated with HMGB1 promoted the proliferation of neuroblastoma cells, and if Beclin 1 is knocked down in Schwann cells, no promotion effects is observed. Taken together, our study demonstrates that HMGB1-induced autophagy in Schwann cells contributes to neuroblastoma cell proliferation, thus providing a potential therapeutic approach on neuroblastoma development.

Entities:  

Keywords:  Autophagy; HMGB1; Schwann cells; neuroblastoma

Mesh:

Substances:

Year:  2015        PMID: 25755740      PMCID: PMC4348936     

Source DB:  PubMed          Journal:  Int J Clin Exp Pathol        ISSN: 1936-2625


  28 in total

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Journal:  Med Pediatr Oncol       Date:  2001-01

Review 5.  'Cross-talk' between Schwannian stroma and neuroblasts promotes neuroblastoma tumor differentiation and inhibits angiogenesis.

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Journal:  Cancer Lett       Date:  2005-10-18       Impact factor: 8.679

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Journal:  Cancer Res       Date:  2000-11-01       Impact factor: 12.701

7.  Schwann cell-conditioned medium promotes neuroblastoma survival and differentiation.

Authors:  J L Kwiatkowski; J L Rutkowski; D J Yamashiro; G I Tennekoon; G M Brodeur
Journal:  Cancer Res       Date:  1998-10-15       Impact factor: 12.701

8.  Emerging role for autophagy in the removal of aggresomes in Schwann cells.

Authors:  Jenny Fortun; William A Dunn; Shale Joy; Jie Li; Lucia Notterpek
Journal:  J Neurosci       Date:  2003-11-19       Impact factor: 6.167

9.  Pigment epithelium-derived factor (PEDF) in neuroblastoma: a multifunctional mediator of Schwann cell antitumor activity.

Authors:  S E Crawford; V Stellmach; M Ranalli; X Huang; L Huang; O Volpert; G H De Vries; L P Abramson; N Bouck
Journal:  J Cell Sci       Date:  2001-12       Impact factor: 5.285

10.  Schwann cells in neuroblastoma express erythropoietin.

Authors:  Domenico Ribatti; Andrea Marzullo; Vito Longo; Luigi Poliani
Journal:  J Neurooncol       Date:  2006-12-13       Impact factor: 4.506

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  6 in total

1.  Action of HMGB1 on miR-221/222 cluster in neuroblastoma cell lines.

Authors:  Emanuela Mari; Alessandra Zicari; Flavia Fico; Isabella Massimi; Lolli Martina; Stefania Mardente
Journal:  Oncol Lett       Date:  2016-07-18       Impact factor: 2.967

Review 2.  The role of high mobility group box 1 (HMGB1) in the pathogenesis of kidney diseases.

Authors:  Qingjie Chen; Xiaofeng Guan; Xiaocong Zuo; Jianglin Wang; Wenjun Yin
Journal:  Acta Pharm Sin B       Date:  2016-03-07       Impact factor: 11.413

3.  Transcription factor E2-2 inhibits the proliferation of endothelial progenitor cells by suppressing autophagy.

Authors:  Li Zhang; Yang Yu; Xi Xia; Yang Ma; Xie-Wan Chen; Zhen-Hong Ni; Hong Wang
Journal:  Int J Mol Med       Date:  2016-03-09       Impact factor: 4.101

4.  MiR-20a-5p suppresses tumor proliferation by targeting autophagy-related gene 7 in neuroblastoma.

Authors:  Yongbo Yu; Jie Zhang; Yaqiong Jin; Yeran Yang; Jin Shi; Feng Chen; Shujing Han; Ping Chu; Jie Lu; Huanmin Wang; Yongli Guo; Xin Ni
Journal:  Cancer Cell Int       Date:  2018-01-04       Impact factor: 5.722

5.  Regulation of Neurogenesis in Mouse Brain by HMGB1.

Authors:  Xiang Zhao; Ari Rouhiainen; Zhilin Li; Su Guo; Heikki Rauvala
Journal:  Cells       Date:  2020-07-17       Impact factor: 6.600

6.  HMGB1 induces apoptosis and EMT in association with increased autophagy following H/R injury in cardiomyocytes.

Authors:  Fan Ouyang; He Huang; Mingyu Zhang; Mingxian Chen; Haobo Huang; Fang Huang; Shenghua Zhou
Journal:  Int J Mol Med       Date:  2016-01-29       Impact factor: 4.101

  6 in total

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