Literature DB >> 25755554

Hemophagocytic Lymphohistiocytosis (HLH) in Children Presenting as Liver Disease.

Nomisha Amin1, Ira Shah1, Sushmita Bhatnagar1.   

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare acute hyperinflammatory condition presenting with high fever, pancytopenia, splenomegaly with the pathologic finding of hemophagocytic lymphohistiocytosis in bone marrow and other tissues. Predominant hepatic manifestations at presentation are rare. We report a series of three cases which showcase the spectrum of liver disease as presentation in hemophagocytic lymphohistiocytosis.

Entities:  

Keywords:  CMV, cytomegalovirus; EBV, Epstein Barr virus; HLH; HLH, hemophagocytic lymphohistiocytosis; LKM, liver–kidney-microsomal; MAS, macrophage activation syndrome; PT, prothrombin time; PTT, partial thromboplastin time; VAHS, virus associated HLH; children; liver disease

Year:  2013        PMID： 25755554      PMCID： PMC4116702          DOI： 10.1016/j.jceh.2013.06.003

Source DB:  PubMed          Journal:  J Clin Exp Hepatol        ISSN： 0973-6883


  10 in total

1.  Hepatic encephalopathy--a presentation of hemophagocytosis.

Authors:  Ira Shah; Susmita Bhatnagar
Journal:  Trop Gastroenterol       Date:  2010 Apr-Jun

2.  HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.

Authors:  Jan-Inge Henter; Annacarin Horne; Maurizio Aricó; R Maarten Egeler; Alexandra H Filipovich; Shinsaku Imashuku; Stephan Ladisch; Ken McClain; David Webb; Jacek Winiarski; Gritta Janka
Journal:  Pediatr Blood Cancer       Date:  2007-02       Impact factor: 3.167

3.  Hemophagocytic lymphohistiocytosis (HLH) and related disorders.

Authors:  Alexandra H Filipovich
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2009

Review 4.  Liver transplant for adult hemophagocytic lymphohistiocytosis: case report and literature review.

Authors:  Gavin Wright; Stephanie Wilmore; Jessica Makanyanga; Thomas McKerrell; Jennifer Watkins; David Patch; Andrew K Burroughs
Journal:  Exp Clin Transplant       Date:  2012-08-23       Impact factor: 0.945

5.  Hemophagocytic syndrome presenting as acute hepatic failure in two infants: clinical overlap with neonatal hemochromatosis.

Authors:  M Parizhskaya; J Reyes; R Jaffe
Journal:  Pediatr Dev Pathol       Date:  1999 Jul-Aug

6.  Histopathology of the liver in histiocytosis syndromes.

Authors:  B E Favara
Journal:  Pediatr Pathol Lab Med       Date:  1996 May-Jun

7.  Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis.

Authors:  K Göransdotter Ericson; B Fadeel; S Nilsson-Ardnor; C Söderhäll; A Samuelsson; G Janka; M Schneider; A Gürgey; N Yalman; T Révész; R Egeler; K Jahnukainen; I Storm-Mathiesen; A Haraldsson ; J Poole; G de Saint Basile; M Nordenskjöld; J Henter
Journal:  Am J Hum Genet       Date:  2001-02-06       Impact factor: 11.025

Review 8.  [Liver involvement in hemophagocytic syndrome].

Authors:  Claire Larroche; Marianne Ziol; Sémia Zidi; Robin Dhote; Dominique Roulot
Journal:  Gastroenterol Clin Biol       Date:  2007-11

9.  Macrophage activation syndrome: characteristic findings on liver biopsy illustrating the key role of activated, IFN-gamma-producing lymphocytes and IL-6- and TNF-alpha-producing macrophages.

Authors:  An D Billiau; Tania Roskams; Rita Van Damme-Lombaerts; Patrick Matthys; Carine Wouters
Journal:  Blood       Date:  2004-10-05       Impact factor: 22.113

Review 10.  Innate immune dysfunction in acute and chronic liver disease.

Authors:  Bettina Leber; Ursula Mayrhauser; Michael Rybczynski; Vanessa Stadlbauer
Journal:  Wien Klin Wochenschr       Date:  2009       Impact factor: 1.704
  10 in total
  1 in total

Review 1.  Inborn Errors of Immunity in the Premature Infant: Challenges in Recognition and Diagnosis.

Authors:  Scott M Gordon; Amy E O'Connell
Journal:  Front Immunol       Date:  2021-12-24       Impact factor: 8.786
  1 in total

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