| Literature DB >> 25755445 |
Mallikarjun Patil1, Keyur A Sheth1, Kullembella S Prasanna1, Channagiri K Adarsh1, Balaraju Girisha1.
Abstract
Spontaneous hematomas in cirrhotic patients are uncommon. Severe coagulopathy in advanced hepatic disease is characterized by both coagulation factor deficiencies and accelerated fibrinolysis. Hyperfibrinolysis in cirrhosis is a result of excess fibrin breakdown leading to defective hemostasis. We present a case of spontaneous hematomas with an acute drop in hemoglobin level, in a patient with cirrhosis which was due to primary hyperfibrinolysis.Entities:
Keywords: DIC, Disseminated intravascular coagulation; EACA, Epsilon amino-caproic acid; FDPs, Fibrin degradation products; PAI-1, Plasminogen activator inhibitor 1; TAFI, Thrombin-activatable fibrinolysis inhibitor; aPTT, Activated partial thromboplastin time; cirrhosis; muscle hematomas; primary hyperfibrinolysis; tPA, Tissue plasminogen activator
Year: 2012 PMID： 25755445 PMCID： PMC3940330 DOI： 10.1016/j.jceh.2012.05.001
Source DB: PubMed Journal: J Clin Exp Hepatol ISSN： 0973-6883