| Literature DB >> 25755308 |
Srinivas Rajagopala1, A Olithselvan1, Joy Varghese1, Naresh Shanmugam1, Mohamed Rela1.
Abstract
Liver transplantation for end-stage liver disease is increasingly being undertaken in India.(1) Routine tuberculin skin testing (TST) for latent Mycobacterium tuberculosis infection (LTBI) and isoniazid prophylaxis in TST-positive liver-transplant recipients (LTRs) is recommended(2,3) but seldom implemented worldwide.(4-7) The role of TST-testing and isoniazid prophylaxis in LTRs remains further undefined in high prevalence areas, including India. We describe the burden of LTBI in LTRs; the epidemiological aspects of M. tuberculosis infection in high prevalence areas; identifiable risk factors for M. tuberculosis infection; the limitations of current diagnostic techniques for LTBI in LTRs and the efficacy and toxicity of isoniazid prophylaxis in TST-positive LTRs and suggest directions for future investigations in this area.Entities:
Keywords: ATT, anti-tuberculosis medications; HCWs, healthcare workers; IGRA, IFN-γ release assays; Isoniazid prophylaxis; LT-TB, liver transplantation tuberculosis; LTBI, latent Mycobacterium tuberculosis infection; LTRs, liver-transplant recipients; SOT, solid-organ transplant; TST, tuberculin skin testing; latent tuberculosis infection; liver transplantation; solid organ transplantation; tuberculosis
Year: 2011 PMID： 25755308 PMCID： PMC3940303 DOI： 10.1016/S0973-6883(11)60120-5
Source DB: PubMed Journal: J Clin Exp Hepatol ISSN： 0973-6883