Literature DB >> 2575481

Cultured human retinal pigment epithelial cells express basic fibroblast growth factor and its receptor.

M D Sternfeld1, J E Robertson, G D Shipley, J Tsai, J T Rosenbaum.   

Abstract

Basic fibroblast growth factor (bFGF) has been implicated in the maintenance of neuronal differentiation, the induction of neovascularization and intravitreal proliferative diseases. We have found that human retinal pigment epithelial (RPE) cells grown in vitro transcribe the bFGF gene and synthesize a peptide that crossreacts with anti-bFGF antibodies. In culture, these cells appear to release activity with biological and biochemical properties similar to bFGF. RPE cells have specific bFGF receptors and proliferate in response to bFGF. Thus, it is possible that the RPE cell is an important source of retinal bFGF and may respond to bFGF in an autocrine manner.

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Year:  1989        PMID： 2575481     DOI： 10.3109/02713688908997395

Source DB:  PubMed          Journal:  Curr Eye Res        ISSN： 0271-3683            Impact factor:   2.424


  15 in total

1.  Transplanted and repopulated retinal pigment epithelial cells on damaged Bruch's membrane in rabbits.

Authors:  C Shiragami; T Matsuo; F Shiraga; N Matsuo
Journal:  Br J Ophthalmol       Date:  1998-09       Impact factor: 4.638

2.  Retinal pigment epithelial cell proliferation: potentiation by monocytes and serum.

Authors:  R Osusky; S J Ryan
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1996-08       Impact factor: 3.117

3.  Scleral cell growth is influenced by retinal pigment epithelium in vitro.

Authors:  Y Seko; Y Tanaka; T Tokoro
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1994-09       Impact factor: 3.117

4.  Protective effect of basic fibroblast growth factor on laser induced retinopathy.

Authors:  Unal Kartal; Emel Koptagel; H Eray Bulut; Haydar Erdogan
Journal:  Int J Ophthalmol       Date:  2013-12-18       Impact factor: 1.779

Review 5.  Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch's membrane/choriocapillaris complex.

Authors:  Imran Bhutto; Gerard Lutty
Journal:  Mol Aspects Med       Date:  2012-04-21

6.  Survival of purified rat photoreceptors in vitro is stimulated directly by fibroblast growth factor-2.

Authors:  V Fontaine; N Kinkl; J Sahel; H Dreyfus; D Hicks
Journal:  J Neurosci       Date:  1998-12-01       Impact factor: 6.167

Review 7.  The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier--implications for the pathogenesis of diabetic retinopathy.

Authors:  Rafael Simó; Marta Villarroel; Lídia Corraliza; Cristina Hernández; Marta Garcia-Ramírez
Journal:  J Biomed Biotechnol       Date:  2010-02-17

8.  Hypoxic induction of endothelial cell growth factors in retinal cells: identification and characterization of vascular endothelial growth factor (VEGF) as the mitogen.

Authors:  D T Shima; A P Adamis; N Ferrara; K T Yeo; T K Yeo; R Allende; J Folkman; P A D'Amore
Journal:  Mol Med       Date:  1995-01       Impact factor: 6.354

9.  Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light.

Authors:  M M LaVail; K Unoki; D Yasumura; M T Matthes; G D Yancopoulos; R H Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

10.  Pro-inflammatory and anti-angiogenic effects of bisphosphonates on human cultured retinal pigment epithelial cells.

Authors:  Chris Or; Jing Cui; Joanne Matsubara; Farzin Forooghian
Journal:  Br J Ophthalmol       Date:  2013-06-13       Impact factor: 4.638
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