Parul U Gandhi1, Hanna K Gaggin1, Arianna M Belcher1, Jamie E Harisiades1, Anna Basile2, Antonia Falco2, Alessandra Rosati2, Federico Piscione3, James L Januzzi1, M Caterina Turco4. 1. Division of Cardiology, Massachusetts General Hospital, Boston, MA, United States. 2. Department of Pharmacy, University of Salerno, Fisciano, SA, Italy; BIOUNIVERSA s.r.l., University of Salerno, Fisciano, SA, Italy. 3. Department of Medicine and Surgery, University of Salerno, Baronissi, SA, Italy. 4. BIOUNIVERSA s.r.l., University of Salerno, Fisciano, SA, Italy; Department of Medicine and Surgery, University of Salerno, Baronissi, SA, Italy. Electronic address: mcturco@unisa.it.
Abstract
BACKGROUND: BCL-2-associated athanogene 3 (BAG3) is a protein implicated in the cardiomyocyte stress response and genesis of cardiomyopathy. Extracellular BAG3 is measurable in patients with heart failure (HF), but the relationship of BAG3 with HF prognosis is unclear. METHODS: BAG3 plasma concentrations were measured in 39 acutely decompensated HF patients; the primary endpoint was death at 1 year. Baseline characteristics were compared by vital status and median BAG3 concentration. Correlation of BAG3 with left ventricular ejection fraction (LVEF) and other biomarkers was performed. Prognostic value was assessed using Cox proportional hazards regression and Kaplan-Meier analysis. RESULTS: At baseline, median BAG3 was significantly higher in decedents (N=11) than survivors (N=28; 1489 ng/mL versus 50 ng/mL; P=0.04); decedents also had worse renal function and higher median natriuretic peptide (NP) and sST2. BAG3 was not significantly correlated with NPs, mid-regional pro-adrenomedullin, sST2, or eGFR, however. Mortality was increased in patients with supra-median BAG3 (>336 ng/mL; 42.1% versus 15.0%, P=0.06). In age and LVEF-adjusted Cox proportional hazards, BAG3 remained a significant mortality predictor (HR=3.20; 95% CI=1.34-7.65; P=0.02); those with supra-median BAG3 had significantly shorter time-to-death (P=0.04). CONCLUSION: The stress response protein BAG3 is measurable in patients with ADHF and may be prognostic for death.
BACKGROUND:BCL-2-associated athanogene 3 (BAG3) is a protein implicated in the cardiomyocyte stress response and genesis of cardiomyopathy. Extracellular BAG3 is measurable in patients with heart failure (HF), but the relationship of BAG3 with HF prognosis is unclear. METHODS:BAG3 plasma concentrations were measured in 39 acutely decompensated HF patients; the primary endpoint was death at 1 year. Baseline characteristics were compared by vital status and median BAG3 concentration. Correlation of BAG3 with left ventricular ejection fraction (LVEF) and other biomarkers was performed. Prognostic value was assessed using Cox proportional hazards regression and Kaplan-Meier analysis. RESULTS: At baseline, median BAG3 was significantly higher in decedents (N=11) than survivors (N=28; 1489 ng/mL versus 50 ng/mL; P=0.04); decedents also had worse renal function and higher median natriuretic peptide (NP) and sST2. BAG3 was not significantly correlated with NPs, mid-regional pro-adrenomedullin, sST2, or eGFR, however. Mortality was increased in patients with supra-median BAG3 (>336 ng/mL; 42.1% versus 15.0%, P=0.06). In age and LVEF-adjusted Cox proportional hazards, BAG3 remained a significant mortality predictor (HR=3.20; 95% CI=1.34-7.65; P=0.02); those with supra-median BAG3 had significantly shorter time-to-death (P=0.04). CONCLUSION: The stress response protein BAG3 is measurable in patients with ADHF and may be prognostic for death.
Authors: S Bollepalli; S Kaye; S Heinonen; J Kaprio; A Rissanen; K A Virtanen; K H Pietiläinen; M Ollikainen Journal: Int J Obes (Lond) Date: 2017-10-05 Impact factor: 5.095
Authors: Albino Carrizzo; Antonio Damato; Mariateresa Ambrosio; Antonia Falco; Alessandra Rosati; Mario Capunzo; Michele Madonna; Maria C Turco; James L Januzzi; Vincenzo De Laurenzi; Carmine Vecchione Journal: Cell Death Dis Date: 2016-10-20 Impact factor: 8.469
Authors: Hye Hyeon Yun; Soon Young Jung; Bong Woo Park; Ji Seung Ko; Kyunghyun Yoo; Jiyoung Yeo; Hong Lim Kim; Hun Jun Park; Ho Joong Youn; Jeong Hwa Lee Journal: Int J Mol Sci Date: 2021-01-29 Impact factor: 5.923
Authors: Mark J Ranek; Marisa J Stachowski; Jonathan A Kirk; Monte S Willis Journal: Philos Trans R Soc Lond B Biol Sci Date: 2018-01-19 Impact factor: 6.237