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Literature DB >> 25753267

MHCI and CD8 lineage commitment. Prolonged access to thymic epithelial MHCI seals CD8⁺ lineage commitment.

Stephen R Daley¹.

Abstract

Entities: Gene

Mesh：

Substances：

Year: 2015 PMID： 25753267 DOI： 10.1038/icb.2015.28

Source DB: PubMed Journal: Immunol Cell Biol ISSN： 0818-9641 Impact factor: 5.126

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References

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10 in total

1. Regulation of Zap70 expression during thymocyte development enables temporal separation of CD4 and CD8 repertoire selection at different signaling thresholds.

Authors: Manoj Saini; Charles Sinclair; Daniel Marshall; Mauro Tolaini; Shimon Sakaguchi; Benedict Seddon
Journal: Sci Signal Date: 2010-03-23 Impact factor: 8.192

2. Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

Authors: Ruka Setoguchi; Masashi Tachibana; Yoshinori Naoe; Sawako Muroi; Kaori Akiyama; Chieko Tezuka; Tsukasa Okuda; Ichiro Taniuchi
Journal: Science Date: 2008-02-08 Impact factor: 47.728

3. Essential role for ZAP-70 in both positive and negative selection of thymocytes.

Authors: I Negishi; N Motoyama; K Nakayama; K Nakayama; S Senju; S Hatakeyama; Q Zhang; A C Chan; D Y Loh
Journal: Nature Date: 1995-08-03 Impact factor: 49.962

4. Normal sequence of phenotypic transitions in one cohort of 5-bromo-2'-deoxyuridine-pulse-labeled thymocytes. Correlation with T cell receptor expression.

Authors: B Lucas; F Vasseur; C Penit
Journal: J Immunol Date: 1993-11-01 Impact factor: 5.422

9. Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.

Authors: Stephen R Daley; Daniel Y Hu; Christopher C Goodnow
Journal: J Exp Med Date: 2013-01-21 Impact factor: 14.307

10. ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage.

Authors: Takeshi Egawa; Dan R Littman
Journal: Nat Immunol Date: 2008-09-07 Impact factor: 25.606

10 in total

MHCI and CD8 lineage commitment. Prolonged access to thymic epithelial MHCI seals CD8⁺ lineage commitment.

1. Regulation of Zap70 expression during thymocyte development enables temporal separation of CD4 and CD8 repertoire selection at different signaling thresholds.

2. Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.

3. Essential role for ZAP-70 in both positive and negative selection of thymocytes.

4. Normal sequence of phenotypic transitions in one cohort of 5-bromo-2'-deoxyuridine-pulse-labeled thymocytes. Correlation with T cell receptor expression.

5. Murine thymic selection quantified using a unique method to capture deleted T cells.

6. Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system.

7. A Zap70-dependent feedback circuit is essential for efficient selection of CD4 lineage thymocytes.

8. Overlapping and asymmetric functions of TCR signaling during thymic selection of CD4 and CD8 lineages.

9. Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.

10. ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage.