Literature DB >> 2575090

The origin of HLA-DR"Br": exon 2 nucleotide sequence implicates possible gene conversion of DR1 by DR4-Dw10, DR5, or DRw6-Dw18.

J L Bidwell1, E A Bidwell, D M Sansom, P T Klouda, B A Bradley.   

Abstract

The exon 2 nucleotide sequences of HLA-DQwl-associated and DQw3-associated HLA-DR"Br" alleles were determined from genomic DNA amplified by the Taq polymerase chain reaction technique. Both alleles reveal identical exon 2 nucleotide sequences. Comparison with other DR alleles suggests that DR"Br" may have originated from DR1 by gene conversion with DR4-Dw10, DR5, or DRw6-Dw18 third hypervariable region sequences.

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Year:  1989        PMID: 2575090     DOI: 10.1016/0198-8859(89)90038-4

Source DB:  PubMed          Journal:  Hum Immunol        ISSN: 0198-8859            Impact factor:   2.850


  2 in total

1.  Nomenclature for factors of the HLA system, 1989. The WHO Nomenclature Committee.

Authors: 
Journal:  Immunogenetics       Date:  1990       Impact factor: 2.846

2.  Sequencing of HLA-D in responders and nonresponders to short ragweed allergen, Amb a V.

Authors:  P Zwollo; E Ehrlich-Kautzky; S J Scharf; A A Ansari; H A Erlich; D G Marsh
Journal:  Immunogenetics       Date:  1991       Impact factor: 2.846

  2 in total

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