Literature DB >> 25750759

Implications of miRNAs in Colorectal Cancer Chemoresistance.

Jingfang Ju1.   

Abstract

With the exponential growth of research efforts on non-coding microRNAs (miRNAs) in the past decade, miRNAs have been demonstrated to be important in many major human diseases, including diabetes, heart disease, and cancer. Due to the broad regulatory function of miRNAs, alterations of their expression can have profound consequences on multiple critical genes and pathways. One of the major issues related to the success of treating advanced colorectal cancer is chemoresistance. In this review, we will present some of the recent advancements in miRNA research related to chemoresistance mechanisms to 5-FU based chemotherapy in colorectal cancer and cancer stem cells. We believe that this miRNA-mediated resistance mechanism will offer novel strategies to develop future anti-cancer therapies.

Entities:  

Year:  2011        PMID： 25750759      PMCID： PMC4350373     

Source DB:  PubMed          Journal:  Int Drug Discov        ISSN： 2150-4792


  45 in total

1.  The colorectal microRNAome.

Authors:  Jordan M Cummins; Yiping He; Rebecca J Leary; Ray Pagliarini; Luis A Diaz; Tobias Sjoblom; Omer Barad; Zvi Bentwich; Anna E Szafranska; Emmanuel Labourier; Christopher K Raymond; Brian S Roberts; Hartmut Juhl; Kenneth W Kinzler; Bert Vogelstein; Victor E Velculescu
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-27       Impact factor: 11.205

2.  Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer.

Authors:  Yaguang Xi; Reut Shalgi; Oystein Fodstad; Yitzhak Pilpel; Jingfang Ju
Journal:  Clin Cancer Res       Date:  2006-04-01       Impact factor: 12.531

3.  Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

Authors:  D Salonga; K D Danenberg; M Johnson; R Metzger; S Groshen; D D Tsao-Wei; H J Lenz; C G Leichman; L Leichman; R B Diasio; P V Danenberg
Journal:  Clin Cancer Res       Date:  2000-04       Impact factor: 12.531

4.  Translational regulation of human p53 gene expression.

Authors:  L Fu; M D Minden; S Benchimol
Journal:  EMBO J       Date:  1996-08-15       Impact factor: 11.598

5.  Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215.

Authors:  Sara A Georges; Matthew C Biery; Soo-Yeon Kim; Janell M Schelter; Jane Guo; Aaron N Chang; Aimee L Jackson; Michael O Carleton; Peter S Linsley; Michele A Cleary; B Nelson Chau
Journal:  Cancer Res       Date:  2008-12-15       Impact factor: 12.701

6.  Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells.

Authors:  Bo Song; Yuan Wang; Matthew A Titmus; Galina Botchkina; Andrea Formentini; Marko Kornmann; Jingfang Ju
Journal:  Mol Cancer       Date:  2010-04-30       Impact factor: 27.401

7.  MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma.

Authors:  Aaron J Schetter; Suet Yi Leung; Jane J Sohn; Krista A Zanetti; Elise D Bowman; Nozomu Yanaihara; Siu Tsan Yuen; Tsun Leung Chan; Dora L W Kwong; Gordon K H Au; Chang-Gong Liu; George A Calin; Carlo M Croce; Curtis C Harris
Journal:  JAMA       Date:  2008-01-30       Impact factor: 56.272

Review 8.  Evaluating the drug-target relationship between thymidylate synthase expression and tumor response to 5-fluorouracil. Is it time to move forward?

Authors:  Shayna L Showalter; Timothy N Showalter; Agnes Witkiewicz; Robert Havens; Eugene P Kennedy; Tomas Hucl; Scott E Kern; Charles J Yeo; Jonathan R Brody
Journal:  Cancer Biol Ther       Date:  2008-04-21       Impact factor: 4.742

9.  Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer.

Authors:  O Slaby; M Svoboda; P Fabian; T Smerdova; D Knoflickova; M Bednarikova; R Nenutil; R Vyzula
Journal:  Oncology       Date:  2008-01-15       Impact factor: 2.935

10.  Prognostic Values of microRNAs in Colorectal Cancer.

Authors:  Yaguang Xi; Andrea Formentini; Minchen Chien; David B Weir; James J Russo; Jingyue Ju; Marko Kornmann; Jingfang Ju
Journal:  Biomark Insights       Date:  2006
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  6 in total

1.  Cancer Stem Cells: An Ever-Hiding Foe.

Authors:  Jacek R Wilczyński
Journal:  Exp Suppl       Date:  2022

2.  Expression profile, molecular functions, and prognostic significance of miRNAs in primary colorectal cancer stem cells.

Authors:  Chuan-Wen Fan; Ran Lu; Chao Fang; Xue-Li Zhang; Zhao-Ying Lv; Yuan Li; Hong Zhang; Zong-Guang Zhou; Xian-Ming Mo; Xiao-Feng Sun
Journal:  Aging (Albany NY)       Date:  2021-04-01       Impact factor: 5.682

Review 3.  Role of miRNA-Regulated Cancer Stem Cells in the Pathogenesis of Human Malignancies.

Authors:  Abdul Q Khan; Eiman I Ahmed; Noor R Elareer; Kulsoom Junejo; Martin Steinhoff; Shahab Uddin
Journal:  Cells       Date:  2019-08-05       Impact factor: 6.600

4.  The lncRNA DLGAP1-AS1/miR-149-5p/TGFB2 axis contributes to colorectal cancer progression and 5-FU resistance by regulating smad2 pathway.

Authors:  Linlin Qu; Yan Chen; Fan Zhang; Liang He
Journal:  Mol Ther Oncolytics       Date:  2021-01-16       Impact factor: 7.200

5.  MicroRNA-425-5p regulates chemoresistance in colorectal cancer cells via regulation of Programmed Cell Death 10.

Authors:  Ye Zhang; Xingqian Hu; Xiaofei Miao; Kuiyu Zhu; Songkui Cui; Qingyang Meng; Jialin Sun; Tong Wang
Journal:  J Cell Mol Med       Date:  2015-12-09       Impact factor: 5.310

Review 6.  Exosomal Non Coding RNA in LIQUID Biopsies as a Promising Biomarker for Colorectal Cancer.

Authors:  Amro Baassiri; Farah Nassar; Deborah Mukherji; Ali Shamseddine; Rihab Nasr; Sally Temraz
Journal:  Int J Mol Sci       Date:  2020-02-19       Impact factor: 5.923
  6 in total

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