Toru Beppu1, Hiromitsu Hayashi2, Hirohisa Okabe2, Katsunori Imai2, Hidetoshi Nitta2, Toshiro Masuda2, Daisuke Hashimoto2, Akira Chikamoto2, Takatoshi Ishiko2, Ken Kikuchi3, Hideo Baba2. 1. Department of Multidisciplinary Treatment for Gastroenterological Cancer, Kumamoto University, Kumamoto, Japan Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan tbeppu@kumamoto-u.ac.jp. 2. Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan. 3. Medical Quality Management Center, Kumamoto University, Kumamoto, Japan.
Abstract
AIM: To clarify the surgical outcome of patients who underwent endoscopic hepatectomy (EH) compared to those of conventional open hepatectomy (OH) for hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Between 1999 and 2011, 269 HCC patients meeting the Milan criteria were divided into EH (n=89) and OH groups (n=180). To equalize the background covariates, a one-to-one propensity case-matched analysis was used. RESULTS: With propensity matching, 52 EH and 52 OH patients showed comparable preoperative clinical characteristics. The operation time (320 min, p=0.049) and the median blood loss (180 g, p<0.001) was significantly lesser with EH, while the median postoperative hospital stay (11 days, p=0.002) was significantly shorter for EH. The cumulative disease-free and overall survival rates were equivalent in both groups. CONCLUSION: EH for HCC patients meeting the Milan criteria is less invasive and might provide an equivalent disease-free and overall survival when compared to conventional OH. Copyright
AIM: To clarify the surgical outcome of patients who underwent endoscopic hepatectomy (EH) compared to those of conventional open hepatectomy (OH) for hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Between 1999 and 2011, 269 HCC patients meeting the Milan criteria were divided into EH (n=89) and OH groups (n=180). To equalize the background covariates, a one-to-one propensity case-matched analysis was used. RESULTS: With propensity matching, 52 EH and 52 OH patients showed comparable preoperative clinical characteristics. The operation time (320 min, p=0.049) and the median blood loss (180 g, p<0.001) was significantly lesser with EH, while the median postoperative hospital stay (11 days, p=0.002) was significantly shorter for EH. The cumulative disease-free and overall survival rates were equivalent in both groups. CONCLUSION: EH for HCC patients meeting the Milan criteria is less invasive and might provide an equivalent disease-free and overall survival when compared to conventional OH. Copyright