Tanja Skyttä1, Suvi Tuohinen2, Vesa Virtanen2, Pekka Raatikainen2, Pirkko-Liisa Kellokumpu-Lehtinen3. 1. Department of Oncology, Tampere University Hospital, University of Tampere, Tampere, Finland School of Medicine, University of Tampere, Tampere, Finland tanja.skytta@pshp.fi tanja.skytta@fimnet.fi. 2. Heart Center, Tampere University Hospital, University of Tampere, Tampere, Finland School of Medicine, University of Tampere, Tampere, Finland. 3. Department of Oncology, Tampere University Hospital, University of Tampere, Tampere, Finland School of Medicine, University of Tampere, Tampere, Finland.
Abstract
AIM: Adjuvant radiotherapy (RT) for left-sided breast cancer has a negative impact on cardiac health. The concurrent use of aromatase inhibitors (AIs) during RT was found to increase the anticancer efficacy of radiation in pre-clinical models. We evaluated whether the acute effects of RT on cardiac functions are augmented by the concurrent use of AIs. PATIENTS AND METHODS: Sixty patients with early-stage left-sided breast cancer underwent a 2D echocardiography, electrocardiogram and cardiac biomarker measurements before and after adjuvant breast RT. Data were analyzed in two groups according to AI use. RESULTS: We observed a significant (p<0.05) decrease in right ventricular systolic function during RT in tricuspid annular plane systolic excursion (TAPSE). TAPSE decreased by 3.0 mm [95% confidence interval (CI)=1.9-4.1 mm] in the AI group and 1.4 mm (95% CI=0.3-2.4 mm) in the non-AI group. In addition, left ventricular diastolic function decreased among patients using AI, as the mitral inflow E-wave decreased 5.8 cm/s (95% CI=1.8-9.7 cm/s) (p=0.006). CONCLUSION: The concurrent use of AI during RT for left-sided breast cancer led to a more pronounced change on right ventricular systolic function and left ventricular diastolic functions compared to RT alone. Copyright
AIM: Adjuvant radiotherapy (RT) for left-sided breast cancer has a negative impact on cardiac health. The concurrent use of aromatase inhibitors (AIs) during RT was found to increase the anticancer efficacy of radiation in pre-clinical models. We evaluated whether the acute effects of RT on cardiac functions are augmented by the concurrent use of AIs. PATIENTS AND METHODS: Sixty patients with early-stage left-sided breast cancer underwent a 2D echocardiography, electrocardiogram and cardiac biomarker measurements before and after adjuvant breast RT. Data were analyzed in two groups according to AI use. RESULTS: We observed a significant (p<0.05) decrease in right ventricular systolic function during RT in tricuspid annular plane systolic excursion (TAPSE). TAPSE decreased by 3.0 mm [95% confidence interval (CI)=1.9-4.1 mm] in the AI group and 1.4 mm (95% CI=0.3-2.4 mm) in the non-AI group. In addition, left ventricular diastolic function decreased among patients using AI, as the mitral inflow E-wave decreased 5.8 cm/s (95% CI=1.8-9.7 cm/s) (p=0.006). CONCLUSION: The concurrent use of AI during RT for left-sided breast cancer led to a more pronounced change on right ventricular systolic function and left ventricular diastolic functions compared to RT alone. Copyright
Authors: Suvi Sirkku Tuohinen; Tanja Skyttä; Vesa Virtanen; Marko Virtanen; Tiina Luukkaala; Pirkko-Liisa Kellokumpu-Lehtinen; Pekka Raatikainen Journal: Int J Cardiovasc Imaging Date: 2016-01-12 Impact factor: 2.357
Authors: Hanna Aula; Tanja Skyttä; Suvi Tuohinen; Tiina Luukkaala; Mari Hämäläinen; Vesa Virtanen; Pekka Raatikainen; Eeva Moilanen; Pirkko-Liisa Kellokumpu-Lehtinen Journal: Breast Date: 2019-12-06 Impact factor: 4.380