Yuuki Iida1, Eiji Sunami2, Hiroharu Yamashita3, Masaya Hiyoshi2, Soichiro Ishihara2, Hironori Yamaguchi2, Asuka Inoue4, Kumiko Makide4, Nelson H Tsuno5, Junken Aoki4, Joji Kitayama2, Toshiaki Watanabe2. 1. Department of Surgical Oncology, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan yiida-tky@umin.ac.jp. 2. Department of Surgical Oncology, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. 3. Department of Gastrointestinal Surgery, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. 4. Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-ku, Sendai, Miyagi, Japan. 5. Department of Transfusion Medicine, Faculty of Medical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Abstract
BACKGROUND: The function of phosphatidylserine-specific phospholipase A1 (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lysophosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA1 in oncogenesis and metastasis of colorectal cancer (CRC). MATERIALS AND METHODS: Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA1. The correlation between PS-PLA1 expression and the clinicopathological variables was analyzed. RESULTS: Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA1 expression. High PS-PLA1 expression was associated with shorter disease-free survival, although it was not an independent predictive factor. CONCLUSION: PS-PLA1 expression in CRC is associated with tumor invasion and metastasis. Copyright
BACKGROUND: The function of phosphatidylserine-specific phospholipase A1 (PS-PLA1), a phospholipase that acts specifically on phosphatidylserine and produces lysophosphatidylserine, a lysophospholipid mediator, has not been fully elucidated. We evaluated the role of PS-PLA1 in oncogenesis and metastasis of colorectal cancer (CRC). MATERIALS AND METHODS: Specimens from 85 patients with CRC were immunostained with a monoclonal antibody against PS-PLA1. The correlation between PS-PLA1 expression and the clinicopathological variables was analyzed. RESULTS:Tumor depth and hematogenous metastasis independently positively correlated with PS-PLA1 expression. High PS-PLA1 expression was associated with shorter disease-free survival, although it was not an independent predictive factor. CONCLUSION:PS-PLA1 expression in CRC is associated with tumor invasion and metastasis. Copyright
Authors: Yang Zhao; Stephan Hasse; Myriam Vaillancourt; Chenqi Zhao; Lynn Davis; Eric Boilard; Paul Fortin; John Di Battista; Patrice E Poubelle; Sylvain G Bourgoin Journal: Int J Mol Sci Date: 2021-11-24 Impact factor: 5.923