Literature DB >> 25750184

Increased levels of HSPA5 in the serum of patients with inflammatory myopathies--preliminary findings.

Fei Xiao1, Jia-Ze Tan, Xiao-Yan Xu, Xue-Feng Wang.   

Abstract

Endoplasmic reticulum (ER) stress is suggested to play an important role in the pathogenesis of myositis recently. The aim of this study was to investigate the serum concentration of an ER stress-specific chaperone protein HSPA5 in patients with inflammatory myopathies. Forty-five patients (27 with polymyositis (PM) and 18 with dermatomyositis (DM)) were included in the study, and all received prednisone therapy. Serum samples were collected from each patient before and after prednisone treatment. Serum HSPA5 levels were detected by enzyme-linked immunosorbent assays. The serum level of HSPA5 was significantly higher in myositis patients than in controls. In addition, the concentrations in the DM subgroup were significantly higher than in the PM groups. Serum HSPA5 levels were positively correlated with creatine kinase (CK) and C-reactive protein (CRP) in PM patients. In patients with DM, the serum HSPA5 concentrations were also found significantly correlated with CK, but not with CRP. After prednisone treatment, serum HSPA5 levels significantly decreased compared to baseline in steroid responders, but no marked decrease was observed in steroid non-responders. Serum HSPA5 is increased in patients with DM and PM. Increased concentrations of HSPA5 in serum may reflect the enhanced ER stress in muscle tissue. Decrease in serum HSPA5 levels appears in patients with clinical remission; therefore, HSPA5 may be a potential biomarker for inflammatory myopathies.

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Year:  2015        PMID: 25750184     DOI: 10.1007/s10067-015-2911-4

Source DB:  PubMed          Journal:  Clin Rheumatol        ISSN: 0770-3198            Impact factor:   2.980


  22 in total

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Review 3.  Endoplasmic reticulum stress in skeletal muscle homeostasis and disease.

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5.  Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation.

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Journal:  Arthritis Res Ther       Date:  2012-04-27       Impact factor: 5.156

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Authors:  Saeed U Khan; Martin Schröder
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10.  Effect of exercise intensity on unfolded protein response in skeletal muscle of rat.

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  5 in total

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Authors:  Omar Ramos-Lopez; Jose I Riezu-Boj; Fermin I Milagro; Maria J Moreno-Aliaga; J Alfredo Martinez
Journal:  Adipocyte       Date:  2018-03-23       Impact factor: 4.534

Review 2.  ER stress in skeletal muscle remodeling and myopathies.

Authors:  Dil Afroze; Ashok Kumar
Journal:  FEBS J       Date:  2017-12-29       Impact factor: 5.542

3.  Change in muscle volume after steroid therapy in patients with myositis assessed using cross-sectional computed tomography.

Authors:  Takashi Nawata; Makoto Kubo; Takafumi Nomura; Keiji Oishi; Kosaku Shiragami; Tadayoshi Ikegami; Munemasa Okada; Shigeki Kobayashi; Masafumi Yano
Journal:  BMC Musculoskelet Disord       Date:  2018-03-27       Impact factor: 2.362

4.  Meta-Analysis of Polymyositis and Dermatomyositis Microarray Data Reveals Novel Genetic Biomarkers.

Authors:  Jaeseung Song; Daeun Kim; Juyeon Hong; Go Woon Kim; Junghyun Jung; Sejin Park; Hee Jung Park; Jong Wha J Joo; Wonhee Jang
Journal:  Genes (Basel)       Date:  2019-10-30       Impact factor: 4.096

5.  Quantitative analysis of protein crotonylation identifies its association with immunoglobulin A nephropathy.

Authors:  Hua Lin; Donge Tang; Yong Xu; Ruohan Zhang; Minglin Ou; Fengping Zheng; Jiejing Chen; Yue Zhang; Guimian Zou; Wen Xue; Yaoshuang Zou; Weier Dai; Weiguo Sui; Yong Dai
Journal:  Mol Med Rep       Date:  2020-01-13       Impact factor: 2.952

  5 in total

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