BACKGROUND: Electrocorticography (ECoG) in brain-injured patients allows to detect spreading depolarization, a potential mechanism of secondary ischemia. Here, we describe the relationship of spreading depolarization with changes in cerebral hemodynamics using a brain tissue probe applying near infrared spectroscopy (NIRS). METHODS: Simultaneous ECoG and NIRS monitoring was performed in a patient with severe aneurysmal subarachnoid hemorrhage. Changes in cerebral blood oxygenation and regional cerebral blood volume were studied before and after the occurrence of spreading depolarization. Cerebral blood flow measurements were performed daily using an indocyanine green dye dilution mode. RESULTS: Single events of spreading depolarizations demonstrated with transient hyperoxic responses and increase in cerebral blood volume. On the other hand, temporal clusters of recurrent spreading depolarizations were associated with prolonged hypoxic responses and decrease in cerebral blood volume. Cerebral blood flow measurements showed higher values before compared to after onset of spreading depolarization (33.7 ± 8.4 vs. 24.2 ± 4.5 ml/100 g/min). CONCLUSIONS: The findings suggest that NIRS monitoring in the cerebral white matter might reflect the hemodynamic signature of spreading depolarization detected by ECoG recordings. This is of potential interest for the further development of both neuromonitoring methods.
BACKGROUND: Electrocorticography (ECoG) in brain-injured patients allows to detect spreading depolarization, a potential mechanism of secondary ischemia. Here, we describe the relationship of spreading depolarization with changes in cerebral hemodynamics using a brain tissue probe applying near infrared spectroscopy (NIRS). METHODS: Simultaneous ECoG and NIRS monitoring was performed in a patient with severe aneurysmal subarachnoid hemorrhage. Changes in cerebral blood oxygenation and regional cerebral blood volume were studied before and after the occurrence of spreading depolarization. Cerebral blood flow measurements were performed daily using an indocyanine green dye dilution mode. RESULTS: Single events of spreading depolarizations demonstrated with transient hyperoxic responses and increase in cerebral blood volume. On the other hand, temporal clusters of recurrent spreading depolarizations were associated with prolonged hypoxic responses and decrease in cerebral blood volume. Cerebral blood flow measurements showed higher values before compared to after onset of spreading depolarization (33.7 ± 8.4 vs. 24.2 ± 4.5 ml/100 g/min). CONCLUSIONS: The findings suggest that NIRS monitoring in the cerebral white matter might reflect the hemodynamic signature of spreading depolarization detected by ECoG recordings. This is of potential interest for the further development of both neuromonitoring methods.
Authors: Anthony J Strong; Martin Fabricius; Martyn G Boutelle; Stuart J Hibbins; Sarah E Hopwood; Robina Jones; Mark C Parkin; Martin Lauritzen Journal: Stroke Date: 2002-12 Impact factor: 7.914
Authors: Anthony J Strong; Peter J Anderson; Helena R Watts; David J Virley; Andrew Lloyd; Elaine A Irving; Toshiaki Nagafuji; Mitsuyoshi Ninomiya; Hajime Nakamura; Andrew K Dunn; Rudolf Graf Journal: Brain Date: 2007-04 Impact factor: 13.501
Authors: Hwa Kyoung Shin; Andrew K Dunn; Phillip B Jones; David A Boas; Michael A Moskowitz; Cenk Ayata Journal: J Cereb Blood Flow Metab Date: 2005-12-07 Impact factor: 6.200
Authors: Bert Bosche; Rudolf Graf; Ralf-Ingo Ernestus; Christian Dohmen; Thomas Reithmeier; Gerrit Brinker; Anthony J Strong; Jens P Dreier; Johannes Woitzik Journal: Ann Neurol Date: 2010-05 Impact factor: 10.422
Authors: Jed A Hartings; Tomas Watanabe; Jens P Dreier; Sebastian Major; Leif Vendelbo; Martin Fabricius Journal: J Neurophysiol Date: 2009-06-03 Impact factor: 2.714
Authors: J P Dreier; K Körner; N Ebert; A Görner; I Rubin; T Back; U Lindauer; T Wolf; A Villringer; K M Einhäupl; M Lauritzen; U Dirnagl Journal: J Cereb Blood Flow Metab Date: 1998-09 Impact factor: 6.200
Authors: Alois J Schiefecker; Mario Kofler; Max Gaasch; Ronny Beer; Iris Unterberger; Bettina Pfausler; Gregor Broessner; Peter Lackner; Paul Rhomberg; Elke Gizewski; Werner O Hackl; Miriam Mulino; Martin Ortler; Claudius Thome; Erich Schmutzhard; Raimund Helbok Journal: J Cereb Blood Flow Metab Date: 2017-04-24 Impact factor: 6.200
Authors: Raimund Helbok; Alois Josef Schiefecker; Christian Friberg; Ronny Beer; Mario Kofler; Paul Rhomberg; Iris Unterberger; Elke Gizewski; John Hauerberg; Kirsten Möller; Peter Lackner; Gregor Broessner; Bettina Pfausler; Martin Ortler; Claudius Thome; Erich Schmutzhard; Martin Fabricius Journal: J Cereb Blood Flow Metab Date: 2016-01-01 Impact factor: 6.200
Authors: Martin Seule; Christopher Sikorski; Oliver Sakowitz; Gord von Campe; Edgar Santos; Berk Orakcioglu; Andreas Unterberg; Emanuela Keller Journal: Neurocrit Care Date: 2016-10 Impact factor: 3.210
Authors: Jens P Dreier; Martin Fabricius; Cenk Ayata; Oliver W Sakowitz; C William Shuttleworth; Christian Dohmen; Rudolf Graf; Peter Vajkoczy; Raimund Helbok; Michiyasu Suzuki; Alois J Schiefecker; Sebastian Major; Maren Kl Winkler; Eun-Jeung Kang; Denny Milakara; Ana I Oliveira-Ferreira; Clemens Reiffurth; Gajanan S Revankar; Kazutaka Sugimoto; Nora F Dengler; Nils Hecht; Brandon Foreman; Bart Feyen; Daniel Kondziella; Christian K Friberg; Henning Piilgaard; Eric S Rosenthal; M Brandon Westover; Anna Maslarova; Edgar Santos; Daniel Hertle; Renán Sánchez-Porras; Sharon L Jewell; Baptiste Balança; Johannes Platz; Jason M Hinzman; Janos Lückl; Karl Schoknecht; Michael Schöll; Christoph Drenckhahn; Delphine Feuerstein; Nina Eriksen; Viktor Horst; Julia S Bretz; Paul Jahnke; Michael Scheel; Georg Bohner; Egill Rostrup; Bente Pakkenberg; Uwe Heinemann; Jan Claassen; Andrew P Carlson; Christina M Kowoll; Svetlana Lublinsky; Yoash Chassidim; Ilan Shelef; Alon Friedman; Gerrit Brinker; Michael Reiner; Sergei A Kirov; R David Andrew; Eszter Farkas; Erdem Güresir; Hartmut Vatter; Lee S Chung; K C Brennan; Thomas Lieutaud; Stephane Marinesco; Andrew Ir Maas; Juan Sahuquillo; Markus A Dahlem; Frank Richter; Oscar Herreras; Martyn G Boutelle; David O Okonkwo; M Ross Bullock; Otto W Witte; Peter Martus; Arn Mjm van den Maagdenberg; Michel D Ferrari; Rick M Dijkhuizen; Lori A Shutter; Norberto Andaluz; André P Schulte; Brian MacVicar; Tomas Watanabe; Johannes Woitzik; Martin Lauritzen; Anthony J Strong; Jed A Hartings Journal: J Cereb Blood Flow Metab Date: 2016-01-01 Impact factor: 6.200