Yuan Tao1, Yu Dong2, Cheng-Wei Lu3, Wei Yang3, Qian Li3. 1. Department of Ophthalmology, the First Hospital of Jilin University, No.71 Xin Min Road, Changchun, 130021, Jilin, China. taoyuanchn@163.com. 2. Department of Ophthalmology, the First Hospital of Jilin University, No.71 Xin Min Road, Changchun, 130021, Jilin, China. dongyu_jl@163.com. 3. Department of Ophthalmology, the First Hospital of Jilin University, No.71 Xin Min Road, Changchun, 130021, Jilin, China.
Abstract
PURPOSE: We aimed to investigate the association between mean platelet volume (MPV) and the occurrence of type 1 retinopathy of prematurity (ROP). MATERIALS AND METHODS: This was a retrospective case-control study. Cases with ROP required laser surgery; controls developed no ROP or stage 1 ROP. Most recent peripheral blood platelet indices before laser (case) and matched age (control) were abstracted. Student's t-test and multivariate logistic regression analysis were used. RESULTS: A significant difference was found in MPV values between infants with ROP and control groups (10.76 ± 1.27 fl, 10.04 ± 0.91 fl, p = 0.0001). No significant differences were found in the mean platelet counts or MPV/Platelet counts between the two groups (p = 0.4151, p = 0.1460, respectively). There was a 1.94-fold increase in the risk of retinopathy of prematurity (OR:1.94; p = 0.005) as the MPV value increased. CONCLUSIONS: Elevated MPV is associated with the occurrence of type 1 ROP. A hypothesis is presented concerning the role of platelets as sequester and deliverer angiogenesis regulators during the neovascularization phase of ROP.
PURPOSE: We aimed to investigate the association between mean platelet volume (MPV) and the occurrence of type 1 retinopathy of prematurity (ROP). MATERIALS AND METHODS: This was a retrospective case-control study. Cases with ROP required laser surgery; controls developed no ROP or stage 1 ROP. Most recent peripheral blood platelet indices before laser (case) and matched age (control) were abstracted. Student's t-test and multivariate logistic regression analysis were used. RESULTS: A significant difference was found in MPV values between infants with ROP and control groups (10.76 ± 1.27 fl, 10.04 ± 0.91 fl, p = 0.0001). No significant differences were found in the mean platelet counts or MPV/Platelet counts between the two groups (p = 0.4151, p = 0.1460, respectively). There was a 1.94-fold increase in the risk of retinopathy of prematurity (OR:1.94; p = 0.005) as the MPV value increased. CONCLUSIONS: Elevated MPV is associated with the occurrence of type 1 ROP. A hypothesis is presented concerning the role of platelets as sequester and deliverer angiogenesis regulators during the neovascularization phase of ROP.
Entities:
Keywords:
Angiogenesis; Infant; Mean platelet volume; Retinopathy of prematurity
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