| Literature DB >> 25749560 |
N Coppola1, R Zampino2, G Bellini3, M Stanzione4, N Capoluongo5, A Marrone2, M Macera5, G Pasquale5, A Boemio2, S Maione3, L E Adinolfi2, E Miraglia Del Giudice6, E Sagnelli5, F Rossi6.
Abstract
The impact of the cannabinoid receptor 2 (CB2) rs35761398 polymorphism on chronic hepatitis B (CHB) was evaluated in 106 consecutive biopsy-proven CHB patients naive for antiviral therapy. A histological activity index (HAI) > 8 (Ishak scoring) was more frequent in patients with CB2-63 RR than in those with CB2-63 QR or QQ (37% vs. 16.7%, p < 0.05). The logistic regression analysis identified CB2-63 RR (p < 0.05) and a fibrosis score >3 (p < 0.005) as independently associated with an HAI >8. The observation that the CB2-63 RR variant is an independent predictor of extensive necroinflammation opens up new prospects in the study of CHB.Entities:
Keywords: Cannabinoid receptor 2; HBV infection; cannabinoid system; chronic hepatitis B; liver disease
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Year: 2015 PMID： 25749560 DOI： 10.1016/j.cmi.2015.02.021
Source DB: PubMed Journal: Clin Microbiol Infect ISSN： 1198-743X Impact factor: 8.067