Can ionization mass spectrometry coupled with ultrasonic scalpel a fine detection method for intraoperative pathological analysis?

Ionization mass spectrometry (IMS) has been reported to detect surgical smoke component and analyze the distribution of phospholipids found in the smoke. Based on the previous studies, electrosurgical and laser knife coupled IMS has been reported to assess pathogenic diagnosis such as tumor malignancy and to guide tumor resection such as real-time surgical margin control. In addition, US operation is a more closed space for smoke detection than the others. Thus, in this study we speculate that ultrasonic scalpel (US) generated smoke could also be detected, which might has a better detection effect and the assessment would has a fine application prospect.