| Literature DB >> 25749339 |
Xiao-Juan Zhong1, Xiao-Dan Shen1, Jian-Bing Wen1, Ying Kong1, Jia-Jia Chu1, Guo-Qiang Yan1, Teng Li1, Dan Liu1, Meng-Qing Wu1, Guo-Hua Zeng1, Ming He1, Qi-Ren Huang2.
Abstract
Recent studies have shown that OPN (osteopontin) plays critical roles in cell survival, differentiation, bio-mineralization, cancer and cardiovascular remodeling. However, its roles in the differentiation of brown adipocytes and the underlying mechanisms remain unclear. Therefore, the aim of this study was to investigate the roles of OPN in the brown adipogenesis and the underlying mechanisms. It was shown that the OPN successfully induced the differentiation of 3T3-L1 white preadipocytes into the PRDM16(+) (PRD1-BF1-RIZ1 homologous domain containing 16) and UCP-1(+) (uncoupling protein-1) brown adipocytes in a concentration and time-dependent manner. Also, activation of PI3K (phosphatidylinositol 3-kinase)-AKT pathway was required for the OPN-induced brown adipogenesis. The findings suggest OPN plays an important role in promoting the differentiation of the brown adipocytes and might provide a potential novel therapeutic approach for the treatment of obesity and related disorders.Entities:
Keywords: Adipocyte; Differentiation; Obesity; Osteopontin; PRDM16
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Year: 2015 PMID： 25749339 DOI： 10.1016/j.bbrc.2015.02.153
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575