Literature DB >> 25748932

Normal and leukemic stem cell niches: insights and therapeutic opportunities.

Koen Schepers1, Timothy B Campbell2, Emmanuelle Passegué3.   

Abstract

Hematopoietic stem cells (HSCs) rely on instructive cues from the bone marrow (BM) niche to maintain their quiescence and adapt blood production to the organism's needs. Alterations in the BM niche are commonly observed in blood malignancies and directly contribute to the aberrant function of disease-initiating leukemic stem cells (LSCs). Here, we review recent insights into the cellular and molecular determinants of the normal HSC niche and describe how genetic changes in stromal cells and leukemia-induced BM niche remodeling contribute to blood malignancies. Moreover, we discuss how these findings can be applied to non-cell-autonomous therapies targeting the LSC niche.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 25748932      PMCID： PMC4391962          DOI： 10.1016/j.stem.2015.02.014

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  118 in total

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Review 2.  The bone marrow microenvironment as a sanctuary for minimal residual disease in CML.

Authors:  Rajesh R Nair; Joel Tolentino; Lori A Hazlehurst
Journal:  Biochem Pharmacol       Date:  2010-04-09       Impact factor: 5.858

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Journal:  Science       Date:  2010-03-26       Impact factor: 47.728

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Journal:  Nature       Date:  2003-10-23       Impact factor: 49.962

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6.  Stem cell transplantation for myelofibrosis: a report from two Canadian centers.

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Journal:  Bone Marrow Transplant       Date:  2003-07       Impact factor: 5.483

Review 7.  Primary myelofibrosis: update on definition, pathogenesis, and treatment.

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Journal:  Annu Rev Med       Date:  2009       Impact factor: 13.739

8.  Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.

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Journal:  Cell Stem Cell       Date:  2010-03-05       Impact factor: 24.633

9.  Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia.

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Journal:  Nature       Date:  2009-06-10       Impact factor: 49.962
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  172 in total

1.  Mechanism and Function of Angiogenin in Hematopoietic Malignancy.

Authors:  Kevin A Goncalves; Guo-Fu Hu
Journal:  Zhongguo Sheng Wu Hua Xue Yu Fen Zi Sheng Wu Xue Bao       Date:  2015-12-23

Review 2.  The bone-marrow niche in MDS and MGUS: implications for AML and MM.

Authors:  Irene M Ghobrial; Alexandre Detappe; Kenneth C Anderson; David P Steensma
Journal:  Nat Rev Clin Oncol       Date:  2018-01-09       Impact factor: 66.675

Review 3.  The potential role of adult stem cells in the management of the rheumatic diseases.

Authors:  Tiziana Franceschetti; Cosimo De Bari
Journal:  Ther Adv Musculoskelet Dis       Date:  2017-04-20       Impact factor: 5.346

4.  Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling.

Authors:  Heather A Himburg; Martina Roos; Tiancheng Fang; Yurun Zhang; Christina M Termini; Lauren Schlussel; Mindy Kim; Amara Pang; Jenny Kan; Liman Zhao; Hyung Suh; Joshua P Sasine; Gopal Sapparapu; Peter M Bowers; Gary Schiller; John P Chute
Journal:  J Clin Invest       Date:  2020-01-02       Impact factor: 14.808

5.  Highly multiplexed proteomic assessment of human bone marrow in acute myeloid leukemia.

Authors:  Haydar Çelik; Katherine E Lindblad; Bogdan Popescu; Gege Gui; Meghali Goswami; Janet Valdez; Christin DeStefano; Catherine Lai; Julie Thompson; Jack Y Ghannam; Giovanna Fantoni; Angélique Biancotto; Julián Candia; Foo Cheung; Gauthaman Sukumar; Clifton L Dalgard; Richard H Smith; Andre Larochelle; Laura W Dillon; Christopher S Hourigan
Journal:  Blood Adv       Date:  2020-01-28

6.  Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML.

Authors:  Rishi V Puram; Monika S Kowalczyk; Carl G de Boer; Rebekka K Schneider; Peter G Miller; Marie McConkey; Zuzana Tothova; Héctor Tejero; Dirk Heckl; Marcus Järås; Michelle C Chen; Hubo Li; Alfred Tamayo; Glenn S Cowley; Orit Rozenblatt-Rosen; Fatima Al-Shahrour; Aviv Regev; Benjamin L Ebert
Journal:  Cell       Date:  2016-04-07       Impact factor: 41.582

7.  Niche signaling promotes stem cell survival in the Drosophila testis via the JAK-STAT target DIAP1.

Authors:  Salman Hasan; Phylis Hétié; Erika L Matunis
Journal:  Dev Biol       Date:  2015-05-01       Impact factor: 3.582

8.  Decellularized Wharton jelly matrix: a biomimetic scaffold for ex vivo hematopoietic stem cell culture.

Authors:  Dandan Li; Grace Chiu; Brea Lipe; Richard A Hopkins; Jacquelyn Lillis; John M Ashton; Soumen Paul; Omar S Aljitawi
Journal:  Blood Adv       Date:  2019-04-09

9.  Exploitation of the neural-hematopoietic stem cell niche axis to treat myeloproliferative neoplasms.

Authors:  Naoimh Herlihy; Claire N Harrison; Donal P McLornan
Journal:  Haematologica       Date:  2019-04       Impact factor: 9.941

Review 10.  Extrinsic regulation of hematopoietic stem cells in development, homeostasis and diseases.

Authors:  Yeojin Lee; Matthew Decker; Heather Lee; Lei Ding
Journal:  Wiley Interdiscip Rev Dev Biol       Date:  2017-05-31       Impact factor: 5.814
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