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Literature DB >> 25748907

Drugging the gut microbiome.

Abstract

Using conventional drug discovery and novel synthetic biology approaches, some investigators and companies are mining our resident microbes and their metabolites for targets in small-molecule drug programs. Ken Garber reports.

Entities: Species

Mesh：

Year: 2015 PMID： 25748907 DOI： 10.1038/nbt.3161

Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908

9 in total

1. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.

Authors: Shin Yoshimoto; Tze Mun Loo; Koji Atarashi; Hiroaki Kanda; Seidai Sato; Seiichi Oyadomari; Yoichiro Iwakura; Kenshiro Oshima; Hidetoshi Morita; Masahira Hattori; Masahisa Hattori; Kenya Honda; Yuichi Ishikawa; Eiji Hara; Naoko Ohtani
Journal: Nature Date: 2013-06-26 Impact factor: 49.962

2. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system.

Authors: Sarkis K Mazmanian; Cui Hua Liu; Arthur O Tzianabos; Dennis L Kasper
Journal: Cell Date: 2005-07-15 Impact factor: 41.582

3. The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.

Authors: Pamela V Chang; Liming Hao; Stefan Offermanns; Ruslan Medzhitov
Journal: Proc Natl Acad Sci U S A Date: 2014-01-03 Impact factor: 11.205

4. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis.

Authors: Aurélien Trompette; Eva S Gollwitzer; Koshika Yadava; Anke K Sichelstiel; Norbert Sprenger; Catherine Ngom-Bru; Carine Blanchard; Tobias Junt; Laurent P Nicod; Nicola L Harris; Benjamin J Marsland
Journal: Nat Med Date: 2014-01-05 Impact factor: 53.440

5. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.

Authors: Elaine Y Hsiao; Sara W McBride; Sophia Hsien; Gil Sharon; Embriette R Hyde; Tyler McCue; Julian A Codelli; Janet Chow; Sarah E Reisman; Joseph F Petrosino; Paul H Patterson; Sarkis K Mazmanian
Journal: Cell Date: 2013-12-05 Impact factor: 41.582

6. Duodenal infusion of donor feces for recurrent Clostridium difficile.

Authors: Els van Nood; Anne Vrieze; Max Nieuwdorp; Susana Fuentes; Erwin G Zoetendal; Willem M de Vos; Caroline E Visser; Ed J Kuijper; Joep F W M Bartelsman; Jan G P Tijssen; Peter Speelman; Marcel G W Dijkgraaf; Josbert J Keller
Journal: N Engl J Med Date: 2013-01-16 Impact factor: 91.245

7. A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics.

Authors: Mohamed S Donia; Peter Cimermancic; Christopher J Schulze; Laura C Wieland Brown; John Martin; Makedonka Mitreva; Jon Clardy; Roger G Linington; Michael A Fischbach
Journal: Cell Date: 2014-09-11 Impact factor: 41.582

8. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota.

Authors: Koji Atarashi; Takeshi Tanoue; Kenshiro Oshima; Wataru Suda; Yuji Nagano; Hiroyoshi Nishikawa; Shinji Fukuda; Takuro Saito; Seiko Narushima; Koji Hase; Sangwan Kim; Joëlle V Fritz; Paul Wilmes; Satoshi Ueha; Kouji Matsushima; Hiroshi Ohno; Bernat Olle; Shimon Sakaguchi; Tadatsugu Taniguchi; Hidetoshi Morita; Masahira Hattori; Kenya Honda
Journal: Nature Date: 2013-07-10 Impact factor: 49.962

9. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.

Authors: Zeneng Wang; Elizabeth Klipfell; Brian J Bennett; Robert Koeth; Bruce S Levison; Brandon Dugar; Ariel E Feldstein; Earl B Britt; Xiaoming Fu; Yoon-Mi Chung; Yuping Wu; Phil Schauer; Jonathan D Smith; Hooman Allayee; W H Wilson Tang; Joseph A DiDonato; Aldons J Lusis; Stanley L Hazen
Journal: Nature Date: 2011-04-07 Impact factor: 49.962

9 in total

19 in total

1. Microbial cocktails join fecal transplants in IBD treatment trials.

Authors: Mark Ratner
Journal: Nat Biotechnol Date: 2015-08 Impact factor: 54.908

Review 2. The role of the gut microbiome in systemic inflammatory disease.

Authors: Jose C Clemente; Julia Manasson; Jose U Scher
Journal: BMJ Date: 2018-01-08

3. Three-dimensional architecture of Vibrio cholera biofilms.

Authors: Gerard C L Wong
Journal: Proc Natl Acad Sci U S A Date: 2016-03-24 Impact factor: 11.205

Review 4. The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists.

Authors: Sunil Thomas; Jacques Izard; Emily Walsh; Kristen Batich; Pakawat Chongsathidkiet; Gerard Clarke; David A Sela; Alexander J Muller; James M Mullin; Korin Albert; John P Gilligan; Katherine DiGuilio; Rima Dilbarova; Walker Alexander; George C Prendergast
Journal: Cancer Res Date: 2017-03-14 Impact factor: 12.701