Literature DB >> 25748799

Enterovirus replication: go with the (counter)flow.

Jules Nchoutmboube1, Lauren A Ford-Siltz1, George A Belov2.   

Abstract

All (+)RNA viruses replicate on distinct membranous domains; however, how they induce and maintain their unique lipid composition is largely unknown. Two recent studies reveal that enteroviruses harness the PI4P-cholestrol exchange cycle driven by OSBP1 protein and PI4 kinase(s), and that blocking the dynamic lipid flow inhibits virus replication.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  cholesterol–PI4P exchange; drug repurposing; enterovirus replication organelles; lipid trafficking; oxysterol binding protein (OSBP)

Mesh：

Substances：

Year:  2015        PMID： 25748799     DOI： 10.1016/j.tim.2015.02.008

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  6 in total

1.  Reconstitution of an RNA Virus Replicase in Artificial Giant Unilamellar Vesicles Supports Full Replication and Provides Protection for the Double-Stranded RNA Replication Intermediate.

Authors:  Nikolay Kovalev; Judit Pogany; Peter D Nagy
Journal:  J Virol       Date:  2020-08-31       Impact factor: 5.103

2.  Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication.

Authors:  Anabel Guedán; Dawid Swieboda; Mark Charles; Marie Toussaint; Sebastian L Johnston; Amin Asfor; Anusha Panjwani; Tobias J Tuthill; Henry Danahay; Tony Raynham; Aurelie Mousnier; Roberto Solari
Journal:  J Virol       Date:  2017-04-13       Impact factor: 5.103

3.  Transient Compound Treatment Induces a Multigenerational Reduction of Oxysterol-Binding Protein (OSBP) Levels and Prophylactic Antiviral Activity.

Authors:  Brett L Roberts; Zachary C Severance; Ryan C Bensen; Anh T Le; Naga Rama Kothapalli; Juan I Nuñez; Hongyan Ma; Si Wu; Shawna J Standke; Zhibo Yang; William J Reddig; Earl L Blewett; Anthony W G Burgett
Journal:  ACS Chem Biol       Date:  2019-01-11       Impact factor: 5.100

4.  Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication.

Authors:  Tao Wang; Bei Wang; He Huang; Chongyang Zhang; Yuanmei Zhu; Bin Pei; Chaofei Cheng; Lei Sun; Jianwei Wang; Qi Jin; Zhendong Zhao
Journal:  PLoS Pathog       Date:  2017-10-06       Impact factor: 6.823

Review 5.  May we target double-membrane vesicles and oxysterol-binding protein to combat SARS-CoV-2 infection?

Authors:  Shiva Shahmohamadnejad; Seyed Fazel Nabavi; Solomon Habtemariam; Kasturi Sarkar; Parames C Sil; Razieh Dowran; Seyed Mohammad Nabavi
Journal:  Cell Biol Int       Date:  2020-06-23       Impact factor: 4.473

6.  PI4KB on Inclusion Bodies Formed by ER Membrane Remodeling Facilitates Replication of Human Parainfluenza Virus Type 3.

Authors:  Zhifei Li; Dong Guo; Yali Qin; Mingzhou Chen
Journal:  Cell Rep       Date:  2019-11-19       Impact factor: 9.423
  6 in total

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