Literature DB >> 25747386

Identification of minimum Rpn4-responsive elements in genes related to proteasome functions.

Ryohei Shirozu1, Hideki Yashiroda1, Shigeo Murata2.   

Abstract

The proteasome is an essential, 66-subunit protease that mediates ubiquitin-dependent proteolysis. The transcription factor Rpn4 regulates concerted expression of proteasome subunits to increase the proteasome by recognizing nonamer proteasome-associated control element (PACE) elements on the promoter regions. However, the genes for proteasome assembly chaperones and some of the subunits have no PACEs. Here we identified a minimal hexamer "PACE-core" sequence that responds to Rpn4. PACE-cores are found in many genes related to proteasome function including the assembly chaperones, but cannot substitute for PACE of the subunits. Our results add a new layer of complexity in transcriptional regulation of genes involved in protein degradation.
Copyright © 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Proteasome; Rpn4; Transcriptional regulation

Mesh：

Substances：

Year:  2015        PMID： 25747386     DOI： 10.1016/j.febslet.2015.02.025

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  21 in total

1.  Proteasome Impairment Induces Recovery of Mitochondrial Membrane Potential and an Alternative Pathway of Mitochondrial Fusion.

Authors:  Ryohei Shirozu; Hideki Yashiroda; Shigeo Murata
Journal:  Mol Cell Biol       Date:  2015-11-09       Impact factor: 4.272

2.  Two alternative mechanisms regulate the onset of chaperone-mediated assembly of the proteasomal ATPases.

Authors:  Asrafun Nahar; Xinyi Fu; George Polovin; James D Orth; Soyeon Park
Journal:  J Biol Chem       Date:  2019-02-27       Impact factor: 5.157

3.  FlbA-Regulated Gene rpnR Is Involved in Stress Resistance and Impacts Protein Secretion when Aspergillus niger Is Grown on Xylose.

Authors:  David Aerts; Stijn G van den Bergh; Harm Post; Maarten A F Altelaar; Mark Arentshorst; Arthur F J Ram; Robin A Ohm; Han A B Wösten
Journal:  Appl Environ Microbiol       Date:  2019-01-09       Impact factor: 4.792

4.  Overexpressing target helper genes enhances secretion and glycosylation of recombinant proteins in Pichia pastoris under simulated microgravity.

Authors:  Jie Huangfu; Yinghua Xu; Chun Li; Jun Li
Journal:  J Ind Microbiol Biotechnol       Date:  2016-08-17       Impact factor: 3.346

Review 5.  The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups.

Authors:  Jerry Vriend; Hassan Marzban
Journal:  Cell Mol Life Sci       Date:  2016-09-03       Impact factor: 9.261

Review 6.  Proteasome Structure and Assembly.

Authors:  Lauren Budenholzer; Chin Leng Cheng; Yanjie Li; Mark Hochstrasser
Journal:  J Mol Biol       Date:  2017-06-03       Impact factor: 5.469

7.  The Proteasome Stress Regulon Is Controlled by a Pair of NAC Transcription Factors in Arabidopsis.

Authors:  Nicholas P Gladman; Richard S Marshall; Kwang-Hee Lee; Richard D Vierstra
Journal:  Plant Cell       Date:  2016-05-18       Impact factor: 11.277

8.  Rpn4 and proteasome-mediated yeast resistance to ethanol includes regulation of autophagy.

Authors:  Julia A Bubis; Daria S Spasskaya; Vladimir A Gorshkov; Frank Kjeldsen; Aleksandra M Kofanova; Dmitry S Lekanov; Mikhail V Gorshkov; Vadim L Karpov; Irina A Tarasova; Dmitry S Karpov
Journal:  Appl Microbiol Biotechnol       Date:  2020-03-10       Impact factor: 4.813

Review 9.  Fine-tuning the ubiquitin-proteasome system to treat pulmonary fibrosis.

Authors:  Willy Roque; Ross Summer; Freddy Romero
Journal:  Connect Tissue Res       Date:  2018-10-22       Impact factor: 3.417

Review 10.  Tuning the proteasome to brighten the end of the journey.

Authors:  Thibault Mayor; Michal Sharon; Michael H Glickman
Journal:  Am J Physiol Cell Physiol       Date:  2016-09-07       Impact factor: 4.249
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.