Literature DB >> 25746894

Suppression of antibiotic resistance acquisition by combined use of antibiotics.

Shingo Suzuki1, Takaaki Horinouchi1, Chikara Furusawa2.   

Abstract

We analyzed the effect of combinatorial use of antibiotics with a trade-off relationship of resistance, i.e., resistance acquisition to one drug causes susceptibility to the other drug, and vice versa, on the evolution of antibiotic resistance. We demonstrated that this combinatorial use of antibiotics significantly suppressed the acquisition of resistance.
Copyright © 2015 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Keywords:  Antibiotics; Escherichia coli; Experimental evolution; Resistance; Trade-off

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Year:  2015        PMID： 25746894     DOI： 10.1016/j.jbiosc.2015.02.003

Source DB:  PubMed          Journal:  J Biosci Bioeng        ISSN： 1347-4421            Impact factor:   2.894


  3 in total

1.  Rapid Evolution of Reduced Susceptibility against a Balanced Dual-Targeting Antibiotic through Stepping-Stone Mutations.

Authors:  Petra Szili; Gábor Draskovits; Tamás Révész; Ferenc Bogár; Dávid Balogh; Tamás Martinek; Lejla Daruka; Réka Spohn; Bálint Márk Vásárhelyi; Márton Czikkely; Bálint Kintses; Gábor Grézal; Györgyi Ferenc; Csaba Pál; Ákos Nyerges
Journal:  Antimicrob Agents Chemother       Date:  2019-08-23       Impact factor: 5.191

2.  Acceleration and suppression of resistance development by antibiotic combinations.

Authors:  Shingo Suzuki; Takaaki Horinouchi; Chikara Furusawa
Journal:  BMC Genomics       Date:  2017-04-26       Impact factor: 3.969

3.  Compatibility of Evolutionary Responses to Constituent Antibiotics Drive Resistance Evolution to Drug Pairs.

Authors:  Leonie Johanna Jahn; Daniel Simon; Mia Jensen; Charles Bradshaw; Mostafa Mostafa Hashim Ellabaan; Morten Otto Alexander Sommer
Journal:  Mol Biol Evol       Date:  2021-05-04       Impact factor: 16.240
  3 in total

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