Tuberculous meningitis on directly observed thrice a week regime.

Sir,

The recent on “tuberculous meningitis on directly observed thrice a week regime” is interesting.[1] Iype et al., noted that “RNTCP regimen was associated with good compliance, comparable mortality and morbidity.[1]” In fact, Iype et al., has ever reported a highly similar observation in Indian Journal of Tuberculosis and concluded that the new regime is not different from classical regime.[2] In fact, although the intermittent short course regime might seem convenient, the efficacy of this regime is still inconclusive. According to the meta-analysis, it is concluded that “Trials conducted to date are insufficient to support or refute the use of intermittent twice- or thrice-weekly, short-course treatment regimens over daily short-course treatment.[3]” In addition, the efficacy of the regime in cases with concomitant illness especially for HIV infection should be further systematically studied.