Jonatan Axelsson1, Lars Rylander2, Anna Rignell-Hydbom2, Christian H Lindh2, Bo A G Jönsson2, Aleksander Giwercman3. 1. Molecular Reproductive Medicine, Skåne University Hospital Malmö, Lund University, 205 02 Malmö, Sweden. Electronic address: jonatan.axelsson@med.lu.se. 2. Division of Occupational and Environmental Medicine, Lund University, 221 85 Lund, Sweden. 3. Molecular Reproductive Medicine, Skåne University Hospital Malmö, Lund University, 205 02 Malmö, Sweden.
Abstract
BACKGROUND: Prenatal exposure to phthalates is suggested to negatively impact male reproductive function, but human data are lacking. OBJECTIVES: To study associations between prenatal exposure to diethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP), and reproductive parameters of adolescent men. METHODS: Using linear regression models adjusted for potential confounders, we studied associations between levels of DEHP- and DiNP metabolites in maternal sera from mean 12 weeks of pregnancy, and testicular size, semen quality and reproductive hormones in 112 adolescent sons, recruited from the general population. RESULTS: Men in the highest exposure tertile of one DiNP metabolite [mono-(carboxy-iso-octyl) phthalate], compared with men in the lowest tertile had: 4.3mL (95% CI: 0.89, 7.6mL; p<0.001) lower total testicular volume; 30% (95% CI: 3.6, 63%; p=0.02) higher levels of follicle-stimulating hormone; and 0.87mL (95% CI: 0.28, 1.5mL; p=0.004) lower semen volume. Men in the highest exposure tertile of one DEHP metabolite [mono-(2-ethyl-5-hydroxylhexyl) phthalate] had 0.70mL (95% CI: 0.090, 1.3mL; p=0.03) lower semen volume than men in the lowest exposure tertile. The levels of two DiNP metabolites [mono-(hydroxy-iso-nonyl) phthalate and mono-(oxo-iso-nonyl) phthalate] were linearly associated with luteinizing hormone (p<0.01). CONCLUSION: Prenatal levels of some metabolites of DEHP and DiNP seemed negatively associated with reproductive function of adolescent men.
BACKGROUND: Prenatal exposure to phthalates is suggested to negatively impact male reproductive function, but human data are lacking. OBJECTIVES: To study associations between prenatal exposure to diethylhexyl phthalate (DEHP) and diisononyl phthalate (DiNP), and reproductive parameters of adolescent men. METHODS: Using linear regression models adjusted for potential confounders, we studied associations between levels of DEHP- and DiNP metabolites in maternal sera from mean 12 weeks of pregnancy, and testicular size, semen quality and reproductive hormones in 112 adolescent sons, recruited from the general population. RESULTS:Men in the highest exposure tertile of one DiNP metabolite [mono-(carboxy-iso-octyl) phthalate], compared with men in the lowest tertile had: 4.3mL (95% CI: 0.89, 7.6mL; p<0.001) lower total testicular volume; 30% (95% CI: 3.6, 63%; p=0.02) higher levels of follicle-stimulating hormone; and 0.87mL (95% CI: 0.28, 1.5mL; p=0.004) lower semen volume. Men in the highest exposure tertile of one DEHP metabolite [mono-(2-ethyl-5-hydroxylhexyl) phthalate] had 0.70mL (95% CI: 0.090, 1.3mL; p=0.03) lower semen volume than men in the lowest exposure tertile. The levels of two DiNP metabolites [mono-(hydroxy-iso-nonyl) phthalate and mono-(oxo-iso-nonyl) phthalate] were linearly associated with luteinizing hormone (p<0.01). CONCLUSION: Prenatal levels of some metabolites of DEHP and DiNP seemed negatively associated with reproductive function of adolescent men.
Authors: Francesco Cargnelutti; Andrea Di Nisio; Francesco Pallotti; Iva Sabovic; Matteo Spaziani; Maria Grazia Tarsitano; Donatella Paoli; Carlo Foresta Journal: Endocrine Date: 2020-08-05 Impact factor: 3.633
Authors: Carrie V Breton; Remy Landon; Linda G Kahn; Michelle Bosquet Enlow; Alicia K Peterson; Theresa Bastain; Joseph Braun; Sarah S Comstock; Cristiane S Duarte; Alison Hipwell; Hong Ji; Janine M LaSalle; Rachel L Miller; Rashelle Musci; Jonathan Posner; Rebecca Schmidt; Shakira F Suglia; Irene Tung; Daniel Weisenberger; Yeyi Zhu; Rebecca Fry Journal: Commun Biol Date: 2021-06-22