Amir Hooshang Mohamadpour1, Leila Abdolrahmani1, Hamed Mirzaei2, Amirhosein Sahebkar3, Mohsen Moohebati4, Maryam Ghorbani5, Gordon A Ferns6, Majid Ghayour-Mobarhan7. 1. Department of Clinical Pharmacy, Pharmaceutical Research Center & School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. 2. Departments of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 3. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 4. Departments of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 5. Departments of Pharmacology and Toxicology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran. 6. Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK. 7. Biochemistry of Nutrition Research Center, Cardiovascular Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: ghayourm@mums.ac.ir.
Abstract
BACKGROUND AND AIMS: Coronary artery disease (CAD) is a common form of vascular disease and is associated with high mortality and morbidity globally. It has been suggested that serum osteopontin (OPN) may be a useful biomarker of atherosclerosis and vascular calcification. The aim of this study was to assess the association between serum OPN levels and severity of CAD. METHODS: Three hundred and four subjects were studied, 111 with clinically significant angiographically defined CAD (CAD+) (>50% stenosis), 96 with negative angiography (CAD-) (<50% stenosis) and 97 healthy controls. Fasting blood samples were collected from all patients before coronary angiography and serum OPN levels were determined using ELISA. RESULTS: Serum concentrations of OPN were significantly higher in both CAD+ (72.99 [51.05-103.64]) and CAD- (11.11 [8.11-18.23]) (p = 0.001) groups compared with the control group (5.99 [4.26-7.91]) (p = 0.001). CAD+ subjects also had higher serum OPN levels compared with CAD-subjects (p = 0.001). However, OPN levels were comparable between subgroups of CAD+ subjects stratified according to the number of narrowed vessels in angiography. CONCLUSIONS: The present results suggest a positive association between circulating OPN concentrations and the presence but not the extent of CAD.
BACKGROUND AND AIMS: Coronary artery disease (CAD) is a common form of vascular disease and is associated with high mortality and morbidity globally. It has been suggested that serum osteopontin (OPN) may be a useful biomarker of atherosclerosis and vascular calcification. The aim of this study was to assess the association between serum OPN levels and severity of CAD. METHODS: Three hundred and four subjects were studied, 111 with clinically significant angiographically defined CAD (CAD+) (>50% stenosis), 96 with negative angiography (CAD-) (<50% stenosis) and 97 healthy controls. Fasting blood samples were collected from all patients before coronary angiography and serum OPN levels were determined using ELISA. RESULTS: Serum concentrations of OPN were significantly higher in both CAD+ (72.99 [51.05-103.64]) and CAD- (11.11 [8.11-18.23]) (p = 0.001) groups compared with the control group (5.99 [4.26-7.91]) (p = 0.001). CAD+ subjects also had higher serum OPN levels compared with CAD-subjects (p = 0.001). However, OPN levels were comparable between subgroups of CAD+ subjects stratified according to the number of narrowed vessels in angiography. CONCLUSIONS: The present results suggest a positive association between circulating OPN concentrations and the presence but not the extent of CAD.
Authors: Sabine R Zwakenberg; Yvonne T van der Schouw; Casper G Schalkwijk; Annemieke M W Spijkerman; Joline W J Beulens Journal: Cardiovasc Diabetol Date: 2018-03-23 Impact factor: 9.951