Literature DB >> 25743872

Healing the orphaned heart: heart failure in a patient with glucose-6-phosphate dehydrogenase deficiency.

Percy Guanzon Balderia1, Supakanya Wongrakpanich1, Monil Patel1, Marjorie Stanek2.   

Abstract

Patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency are not represented in clinical trials for heart failure. Moreover, many of the recommended medications can cause haemolysis in this group of patients. We present the case of a 71-year-old woman with G6PD deficiency admitted for acute non-ischemic heart failure with reduced ejection fraction. Our experience showed that a combination of ethacrynic acid and spironolactone is safe and effective for relief of volume overload in this group of patients. Studies are needed to determine whether the morbidity and mortality benefits of established heart failure regimens extend to patients with G6PD deficiency. 2015 BMJ Publishing Group Ltd.

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Year:  2015        PMID： 25743872      PMCID： PMC4368920          DOI： 10.1136/bcr-2015-209365

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN： 1757-790X


  12 in total

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Journal:  J Am Coll Cardiol       Date:  2013-06-05       Impact factor: 24.094

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Journal:  Nat Med       Date:  2007-02-04       Impact factor: 53.440

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Authors:  W K Long; S W Wilson; E P Frenkel
Journal:  Am J Hum Genet       Date:  1967-01       Impact factor: 11.025

4.  Elevated blood pressure, pulse rate and serum creatinine in Negro males deficient in glucose-6-phosphate dehydrogenase.

Authors:  S L Wiesenfeld; N L Petrakis; B J Sams; M F Collen; J L Cutler
Journal:  N Engl J Med       Date:  1970-04-30       Impact factor: 91.245

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Authors:  E Beutler
Journal:  Blood       Date:  1994-12-01       Impact factor: 22.113

6.  The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.

Authors:  B Pitt; F Zannad; W J Remme; R Cody; A Castaigne; A Perez; J Palensky; J Wittes
Journal:  N Engl J Med       Date:  1999-09-02       Impact factor: 91.245

7.  Mortality in a cohort of men expressing the glucose-6-phosphate dehydrogenase deficiency.

Authors:  P Cocco; P Todde; S Fornera; M B Manca; P Manca; A R Sias
Journal:  Blood       Date:  1998-01-15       Impact factor: 22.113

Review 8.  The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis.

Authors:  Ella T Nkhoma; Charles Poole; Vani Vannappagari; Susan A Hall; Ernest Beutler
Journal:  Blood Cells Mol Dis       Date:  2009-02-23       Impact factor: 3.039

9.  The clinical pharmacology of ethacrynic acid.

Authors:  Janos Molnar; John C Somberg
Journal:  Am J Ther       Date:  2009 Jan-Feb       Impact factor: 2.688

Review 10.  Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease.

Authors:  Peter A Hecker; Jane A Leopold; Sachin A Gupte; Fabio A Recchia; William C Stanley
Journal:  Am J Physiol Heart Circ Physiol       Date:  2012-12-15       Impact factor: 4.733
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