Yuhong Tang1, Hualin Song2, Yali Bao3, Yang Zhi4. 1. Hebei North University, Laboratory Medicine College, Zhangjiakou, Hebei Province, China. 2. Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin, China. 3. Department of Pathology, The Second Hospital of Tianjin Medical University, Tianjin, China. 4. Department of Ultrasound, Binzhou Medical University Hospital, Binzhou, Shandong Province 256600, China. Electronic address: suixiang1@126.com.
Abstract
OBJECTIVE: To investigate the clinicopathologic features and survival outcomes of desmoplastic small round cell tumor (DSCRT). METHODS: The retrospective cohort study was performed on clinical and pathological data of 18 DSCRT patients. Among them, two subgroups were classified according to treatment modalities. 10 cases underwent operation and adjuvant chemotherapy (group 1, 10/18, 55.6%) and 8 cases were diagnosed by fine needle aspiration biopsy without surgical intervention (group 2, 8/18, 44.4%). All cases received six courses of multiple agents chemotherapy. RESULTS: All cases were histologically confirmed as DSRCT and Cox regression revealed that sex, tumor localization and treatment modality affected patient outcomes. Kaplan-Meier analysis revealed that the median survival time was 22.0 ± 4.0 mo in group 1 versus 9.0 ± 0.7 mo in group 2. CONCLUSION: DSRCT is highly aggressive malignance with poor prognosis, surgical excision with combination of chemotherapy can significantly improve the survival outcomes.
OBJECTIVE: To investigate the clinicopathologic features and survival outcomes of desmoplastic small round cell tumor (DSCRT). METHODS: The retrospective cohort study was performed on clinical and pathological data of 18 DSCRT patients. Among them, two subgroups were classified according to treatment modalities. 10 cases underwent operation and adjuvant chemotherapy (group 1, 10/18, 55.6%) and 8 cases were diagnosed by fine needle aspiration biopsy without surgical intervention (group 2, 8/18, 44.4%). All cases received six courses of multiple agents chemotherapy. RESULTS: All cases were histologically confirmed as DSRCT and Cox regression revealed that sex, tumor localization and treatment modality affected patient outcomes. Kaplan-Meier analysis revealed that the median survival time was 22.0 ± 4.0 mo in group 1 versus 9.0 ± 0.7 mo in group 2. CONCLUSION: DSRCT is highly aggressive malignance with poor prognosis, surgical excision with combination of chemotherapy can significantly improve the survival outcomes.
Authors: N Tsoukalas; M Kiakou; G Nakos; M Tolia; M Galanopoulos; K Tsapakidis; K Kamposioras; C Christofyllakis; G Dimitrakopoulos; D Sambaziotis Journal: Ann R Coll Surg Engl Date: 2020-01-24 Impact factor: 1.891
Authors: Fernando Campos; Daniel L Coutinho; Maria Letícia G Silva; Ademar Lopes; Antônio Nascimento; Samuel Aguiar Júnior; Ulisses R Nicolau; Maria Nirvana Formiga; Felipe D'Almeida Costa; Celso Mello Journal: Sarcoma Date: 2020-10-28