Ji Hye Huh1, EunHee Choi2, Jung Soo Lim1, Mi Young Lee1, Choon Hee Chung1, Jang Yel Shin3. 1. Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju-Si, Republic of Korea. 2. Institute of Lifestyle Medicine, Yonsei University, Wonju College of Medicine, Wonju-Si, Republic of Korea. 3. Department of Internal Medicine, Yonsei University, Wonju College of Medicine, Wonju-Si, Republic of Korea. Electronic address: sjy3290@yonsei.ac.kr.
Abstract
AIMS: We investigated the association between serum cystatin C and asymptomatic peripheral artery disease (PAD) in type 2 diabetes mellitus patients with normal renal function or mild renal impairment and we compared cystatin C with albuminuria and estimated glomerular filtration rate (eGFR) for prediction of PAD. METHODS: We enrolled 272 patients with type 2 diabetes. Patients were excluded if they had an eGFR<60mL/min per 1.73m(2), 24-h urine albumin (24h-uAlb)≥300mg/day, serum creatinine (Cr)>1.3mg/dL, or previous history of cardiovascular disease. PAD was defined as having an ankle brachial index (ABI)≤0.9. RESULTS: Patients with PAD were more likely to have a lower eGFR and higher values of 24h-uAlb, cystatin C, and serum Cr than subjects without PAD. Cystatin C was independently associated with age, current smoking, HDL, eGFR, and PAD. Odds ratios (ORs) for PAD after adjustment for age, gender, smoking, and hypertension were 1.71 (95% CI, 1.02-2.85), 1.51 (95% CI, 0.93-2.44), and 0.78 (95% CI, 0.41-1.49) for a one standard deviation increase in cystatin C, 24h-uAlb, and eGFR, respectively. CONCLUSIONS: Cystatin C was independently associated with PAD in type 2 diabetes mellitus patients without overt nephropathy.
AIMS: We investigated the association between serum cystatin C and asymptomatic peripheral artery disease (PAD) in type 2 diabetes mellituspatients with normal renal function or mild renal impairment and we compared cystatin C with albuminuria and estimated glomerular filtration rate (eGFR) for prediction of PAD. METHODS: We enrolled 272 patients with type 2 diabetes. Patients were excluded if they had an eGFR<60mL/min per 1.73m(2), 24-h urine albumin (24h-uAlb)≥300mg/day, serum creatinine (Cr)>1.3mg/dL, or previous history of cardiovascular disease. PAD was defined as having an ankle brachial index (ABI)≤0.9. RESULTS:Patients with PAD were more likely to have a lower eGFR and higher values of 24h-uAlb, cystatin C, and serum Cr than subjects without PAD. Cystatin C was independently associated with age, current smoking, HDL, eGFR, and PAD. Odds ratios (ORs) for PAD after adjustment for age, gender, smoking, and hypertension were 1.71 (95% CI, 1.02-2.85), 1.51 (95% CI, 0.93-2.44), and 0.78 (95% CI, 0.41-1.49) for a one standard deviation increase in cystatin C, 24h-uAlb, and eGFR, respectively. CONCLUSIONS:Cystatin C was independently associated with PAD in type 2 diabetes mellituspatients without overt nephropathy.
Authors: Qing Yang; Mei Zhang; Peng Sun; Yanying Li; Huichao Xu; Kejun Wang; Hongshan Shen; Bo Ban; Fupeng Liu Journal: BMJ Open Diabetes Res Care Date: 2021-11
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