Krishna Prasad Shetty1, Sarvepalli Venkata Satish2, Krishna Rao Kilaru3, Poonam Sardar2, Alexander M Luke4. 1. Department of Conservative Dentistry and Endodontics, Navodaya Dental College and Hospital, Karnataka, India. Electronic address: kprasad11@yahoo.com. 2. Department of Conservative Dentistry and Endodontics, Navodaya Dental College and Hospital, Karnataka, India. 3. Department of Restorative Dental Sciences, College of Dentistry, King Khalid University, Abha, Saudi Arabia. 4. College of Dentistry, Ajman University of Science and Technology, Ajman, United Arab Emirates.
Abstract
INTRODUCTION: The purpose of this prospective, randomized, double-blind, placebo-controlled study was to compare the anesthetic efficacy between lidocaine with and without magnesium sulfate USP 50% for inferior alveolar nerve (IAN) blocks in patients with symptomatic irreversible pulpitis. METHODS:One hundred patients with symptomatic irreversible pulpitis of mandibular posterior teeth were selected for the study. The patients received 1 mL magnesium sulfate USP 50% or distilled water (placebo) 1 hour before administration of conventional IAN block. Endodontic access cavity preparation was initiated 15 minutes after the IAN block injection. Lip numbness was recorded for all the patients. Success of IAN block was defined as no or mild pain on the visual analogue scale during access cavity preparation and initial instrumentation. RESULTS: The success rate for the IAN block was 58% for magnesium sulfate group and 32% for the placebo group, with statistically significant difference between the 2 groups (P = .016). CONCLUSIONS: In mandibular posterior teeth diagnosed with symptomatic irreversible pulpitis, preoperative administration of 1mL magnesium sulfate USP 50% resulted in statistically significant increase in success of IAN block compared with placebo.
RCT Entities:
INTRODUCTION: The purpose of this prospective, randomized, double-blind, placebo-controlled study was to compare the anesthetic efficacy between lidocaine with and without magnesium sulfateUSP 50% for inferior alveolar nerve (IAN) blocks in patients with symptomatic irreversible pulpitis. METHODS: One hundred patients with symptomatic irreversible pulpitis of mandibular posterior teeth were selected for the study. The patients received 1 mL magnesium sulfateUSP 50% or distilled water (placebo) 1 hour before administration of conventional IAN block. Endodontic access cavity preparation was initiated 15 minutes after the IAN block injection. Lip numbness was recorded for all the patients. Success of IAN block was defined as no or mild pain on the visual analogue scale during access cavity preparation and initial instrumentation. RESULTS: The success rate for the IAN block was 58% for magnesium sulfate group and 32% for the placebo group, with statistically significant difference between the 2 groups (P = .016). CONCLUSIONS: In mandibular posterior teeth diagnosed with symptomatic irreversible pulpitis, preoperative administration of 1 mL magnesium sulfateUSP 50% resulted in statistically significant increase in success of IAN block compared with placebo.