Literature DB >> 25742273

The use of halloysite clay and carboxyl-functionalised multi-walled carbon nanotubes for recombinant LipL32 antigen delivery enhanced the IgG response.

Daiane D Hartwig1, Kátia L Bacelo1, Thaís L Oliveira1, Rodrigo Schuch1, Fabiana K Seixas1, Tiago Collares1, Oscar Rodrigues2, Cláudia P Hartleben1, Odir A Dellagostin1.   

Abstract

We studied the feasibility of using halloysite clay nanotubes (HNTs) and carboxyl-functionalised multi-walled carbon nanotubes (COOH-MWCNTs) as antigen carriers to improve immune responses against a recombinant LipL32 protein (rLipL32). Immunisation using the HNTs or COOH-MWCNTs significantly increased the rLipL32-specific IgG antibody titres (p < 0.05) of Golden Syrian hamsters. None of the vaccines tested conferred protection against a challenge using a virulent Leptospira interrogans strain. These results demonstrated that nanotubes can be used as antigen carriers for delivery in hosts and the induction of a humoral immune response against purified leptospiral antigens used in subunit vaccine preparations.

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Year:  2015        PMID： 25742273      PMCID： PMC4371227          DOI： 10.1590/0074-02760140276

Source DB:  PubMed          Journal:  Mem Inst Oswaldo Cruz        ISSN： 0074-0276            Impact factor:   2.743


  30 in total

Review 1.  Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics.

Authors:  Cédric Klumpp; Kostas Kostarelos; Maurizio Prato; Alberto Bianco
Journal:  Biochim Biophys Acta       Date:  2005-11-09

Review 2.  Biomedical applications of functionalised carbon nanotubes.

Authors:  Alberto Bianco; Kostas Kostarelos; Charalambos D Partidos; Maurizio Prato
Journal:  Chem Commun (Camb)       Date:  2004-12-21       Impact factor: 6.222

3.  Carbon nanotube delivery of the GFP gene into mammalian cells.

Authors:  Lizeng Gao; Leng Nie; Taihong Wang; Yujun Qin; Zhixin Guo; Dongling Yang; Xiyun Yan
Journal:  Chembiochem       Date:  2006-02       Impact factor: 3.164

4.  Immunogenicity of the recombinant leptospiral putative outer membrane proteins as vaccine candidates.

Authors:  Yung-Fu Chang; Chia-Sui Chen; Raghavan U M Palaniappan; Hongxuan He; Sean P McDonough; Steve C Barr; Weiwei Yan; Syed M Faisal; Ming-Jeng Pan; Chao-Fu Chang
Journal:  Vaccine       Date:  2007-09-29       Impact factor: 3.641

Review 5.  Leptospirosis: pathogenesis, immunity, and diagnosis.

Authors:  Raghavan U M Palaniappan; Subbupoongothai Ramanujam; Yung-Fu Chang
Journal:  Curr Opin Infect Dis       Date:  2007-06       Impact factor: 4.915

6.  Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction.

Authors:  Nadine Wong Shi Kam; Michael O'Connell; Jeffrey A Wisdom; Hongjie Dai
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-08       Impact factor: 11.205

7.  Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells.

Authors:  Hélène Dumortier; Stéphanie Lacotte; Giorgia Pastorin; Riccardo Marega; Wei Wu; Davide Bonifazi; Jean-Paul Briand; Maurizio Prato; Sylviane Muller; Alberto Bianco
Journal:  Nano Lett       Date:  2006-07       Impact factor: 11.189

8.  Immunoprotection of recombinant leptospiral immunoglobulin-like protein A against Leptospira interrogans serovar Pomona infection.

Authors:  Raghavan U M Palaniappan; Sean P McDonough; Thomas J Divers; Chia-Sui Chen; Ming-Jeng Pan; Mitsuharu Matsumoto; Yung-Fu Chang
Journal:  Infect Immun       Date:  2006-03       Impact factor: 3.441

9.  Recombinant Mycobacterium bovis BCG expressing the LipL32 antigen of Leptospira interrogans protects hamsters from challenge.

Authors:  Fabiana Kömmling Seixas; Everton Fagonde da Silva; Daiane Drawanz Hartwig; Gustavo Maia Cerqueira; Marta Amaral; Michel Quevedo Fagundes; Robson Grando Dossa; Odir Antônio Dellagostin
Journal:  Vaccine       Date:  2007-11-12       Impact factor: 3.641

10.  The terminal portion of leptospiral immunoglobulin-like protein LigA confers protective immunity against lethal infection in the hamster model of leptospirosis.

Authors:  Everton F Silva; Marco A Medeiros; Alan J A McBride; Jim Matsunaga; Gabriela S Esteves; João G R Ramos; Cleiton S Santos; Júlio Croda; Akira Homma; Odir A Dellagostin; David A Haake; Mitermayer G Reis; Albert I Ko
Journal:  Vaccine       Date:  2007-06-14       Impact factor: 3.641
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  3 in total

1.  DNA nanovaccines prepared using LemA antigen protect Golden Syrian hamsters against Leptospira lethal infection.

Authors:  Thaís Larré Oliveira; Kátia Leston Bacelo; Karine Maciel Forster; Vinicius Ilha; Oscar Endrigo Rodrigues; Daiane D Hartwig
Journal:  Mem Inst Oswaldo Cruz       Date:  2020-04-17       Impact factor: 2.743

Review 2.  Application of Halloysite Nanotubes in Cancer Therapy-A Review.

Authors:  Anna Karewicz; Adrianna Machowska; Martyna Kasprzyk; Gabriela Ledwójcik
Journal:  Materials (Basel)       Date:  2021-05-29       Impact factor: 3.623

3.  Immune response in hamsters immunised with a recombinant fragment of LigA from Leptospira interrogans, associated with carrier molecules.

Authors:  Thaís L Oliveira; Kátia L Bacelo; Rodrigo A Schuch; Fabiana K Seixas; Tiago Collares; Oscar Ed Rodrigues; Josimar Vargas; Rafaella O do Nascimento; Odir A Dellagostin; Daiane D Hartwig
Journal:  Mem Inst Oswaldo Cruz       Date:  2016-10-13       Impact factor: 2.743
  3 in total

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