Literature DB >> 25741013

Ebola virus VP35 interaction with dynein LC8 regulates viral RNA synthesis.

Priya Luthra1, David S Jordan2, Daisy W Leung2, Gaya K Amarasinghe2, Christopher F Basler3.   

Abstract

Ebola virus VP35 inhibits alpha/beta interferon production and functions as a viral polymerase cofactor. Previously, the 8-kDa cytoplasmic dynein light chain (LC8) was demonstrated to interact with VP35, but the functional consequences were unclear. Here we demonstrate that the interaction is direct and of high affinity and that binding stabilizes the VP35 N-terminal oligomerization domain and enhances viral RNA synthesis. Mutational analysis demonstrates that VP35 interaction is required for the functional effects of LC8.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25741013      PMCID： PMC4403485          DOI： 10.1128/JVI.03652-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  33 in total

1.  Interaction of the rabies virus P protein with the LC8 dynein light chain.

Authors:  H Raux; A Flamand; D Blondel
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

2.  Identification of novel cellular proteins that bind to the LC8 dynein light chain using a pepscan technique.

Authors:  I Rodríguez-Crespo; B Yélamos; F Roncal; J P Albar; P R Ortiz de Montellano; F Gavilanes
Journal:  FEBS Lett       Date:  2001-08-17       Impact factor: 4.124

3.  The Ebola virus VP35 protein functions as a type I IFN antagonist.

Authors:  C F Basler; X Wang; E Mühlberger; V Volchkov; J Paragas; H D Klenk; A García-Sastre; P Palese
Journal:  Proc Natl Acad Sci U S A       Date:  2000-10-24       Impact factor: 11.205

4.  Recognition of novel viral sequences that associate with the dynein light chain LC8 identified through a pepscan technique.

Authors:  Mónica Martínez-Moreno; Inmaculada Navarro-Lérida; Fernando Roncal; Juan Pablo Albar; Covadonga Alonso; Francisco Gavilanes; Ignacio Rodríguez-Crespo
Journal:  FEBS Lett       Date:  2003-06-05       Impact factor: 4.124

5.  Structure of the monomeric 8-kDa dynein light chain and mechanism of the domain-swapped dimer assembly.

Authors:  Wenning Wang; Kevin W-H Lo; Ho-Man Kan; Jing-Song Fan; Mingjie Zhang
Journal:  J Biol Chem       Date:  2003-08-06       Impact factor: 5.157

6.  A C-terminal basic amino acid motif of Zaire ebolavirus VP35 is essential for type I interferon antagonism and displays high identity with the RNA-binding domain of another interferon antagonist, the NS1 protein of influenza A virus.

Authors:  Amy L Hartman; Jonathan S Towner; Stuart T Nichol
Journal:  Virology       Date:  2004-10-25       Impact factor: 3.616

7.  On the domain structure and the polymerization state of the sendai virus P protein.

Authors:  N Tarbouriech; J Curran; C Ebel; R W Ruigrok; W P Burmeister
Journal:  Virology       Date:  2000-01-05       Impact factor: 3.616

8.  African swine fever virus protein p54 interacts with the microtubular motor complex through direct binding to light-chain dynein.

Authors:  C Alonso; J Miskin; B Hernáez; P Fernandez-Zapatero; L Soto; C Cantó; I Rodríguez-Crespo; L Dixon; J M Escribano
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

9.  Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport.

Authors:  Mark W Douglas; Russell J Diefenbach; Fred L Homa; Monica Miranda-Saksena; Frazer J Rixon; Valerio Vittone; Karen Byth; Anthony L Cunningham
Journal:  J Biol Chem       Date:  2004-04-26       Impact factor: 5.157

10.  The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.

Authors:  Christopher F Basler; Andrea Mikulasova; Luis Martinez-Sobrido; Jason Paragas; Elke Mühlberger; Mike Bray; Hans-Dieter Klenk; Peter Palese; Adolfo García-Sastre
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103
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  25 in total

1.  Ebola virus VP35 has novel NTPase and helicase-like activities.

Authors:  Ting Shu; Tianyu Gan; Peng Bai; Xiaotong Wang; Qi Qian; Hui Zhou; Qi Cheng; Yang Qiu; Lei Yin; Jin Zhong; Xi Zhou
Journal:  Nucleic Acids Res       Date:  2019-06-20       Impact factor: 16.971

2.  A Dynein Light Chain 1 Binding Motif in Rabies Virus Polymerase L Protein Plays a Role in Microtubule Reorganization and Viral Primary Transcription.

Authors:  Anja Bauer; Tobias Nolden; Sabine Nemitz; Eran Perlson; Stefan Finke
Journal:  J Virol       Date:  2015-07-08       Impact factor: 5.103

3.  RNA Binding of Ebola Virus VP30 Is Essential for Activating Viral Transcription.

Authors:  Nadine Biedenkopf; Julia Schlereth; Arnold Grünweller; Stephan Becker; Roland K Hartmann
Journal:  J Virol       Date:  2016-07-27       Impact factor: 5.103

Review 4.  How order and disorder within paramyxoviral nucleoproteins and phosphoproteins orchestrate the molecular interplay of transcription and replication.

Authors:  Sonia Longhi; Louis-Marie Bloyet; Stefano Gianni; Denis Gerlier
Journal:  Cell Mol Life Sci       Date:  2017-06-09       Impact factor: 9.261

5.  Crystal Structure of the Marburg Virus VP35 Oligomerization Domain.

Authors:  Jessica F Bruhn; Robert N Kirchdoerfer; Sarah M Urata; Sheng Li; Ian J Tickle; Gérard Bricogne; Erica Ollmann Saphire
Journal:  J Virol       Date:  2017-01-03       Impact factor: 5.103

6.  Measles Virus Forms Inclusion Bodies with Properties of Liquid Organelles.

Authors:  Yuqin Zhou; Justin M Su; Charles E Samuel; Dzwokai Ma
Journal:  J Virol       Date:  2019-10-15       Impact factor: 5.103

7.  Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses.

Authors:  Priya Luthra; Jacinth Naidoo; Colette A Pietzsch; Sampriti De; Sudip Khadka; Manu Anantpadma; Caroline G Williams; Megan R Edwards; Robert A Davey; Alexander Bukreyev; Joseph M Ready; Christopher F Basler
Journal:  Antiviral Res       Date:  2018-08-23       Impact factor: 5.970

Review 8.  Multivalent IDP assemblies: Unique properties of LC8-associated, IDP duplex scaffolds.

Authors:  Sarah A Clark; Nathan Jespersen; Clare Woodward; Elisar Barbar
Journal:  FEBS Lett       Date:  2015-07-29       Impact factor: 4.124

9.  Dynein Light Chain LC8 Is Required for RNA Polymerase I-Mediated Transcription in Trypanosoma brucei, Facilitating Assembly and Promoter Binding of Class I Transcription Factor A.

Authors:  Justin K Kirkham; Sung Hee Park; Tu N Nguyen; Ju Huck Lee; Arthur Günzl
Journal:  Mol Cell Biol       Date:  2015-10-12       Impact factor: 4.272

10.  Conservation of Structure and Immune Antagonist Functions of Filoviral VP35 Homologs Present in Microbat Genomes.

Authors:  Megan R Edwards; Hejun Liu; Reed S Shabman; Garrett M Ginell; Priya Luthra; Parmeshwaran Ramanan; Lisa J Keefe; Bernd Köllner; Gaya K Amarasinghe; Derek J Taylor; Daisy W Leung; Christopher F Basler
Journal:  Cell Rep       Date:  2018-07-24       Impact factor: 9.423
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